HDGF Antibody (E-7): sc-271344

HDGF Antibody (E-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects HDGF protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-HDGF antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Hepatoma Derived Growth Factor (HDGF) plays a crucial role in cellular processes, particularly in promoting cell proliferation and tissue repair. HDGF is primarily located in the nucleus and cytoplasm of smooth muscle and endothelial cells, where HDGF expression is vital for vascular development and remodeling. Notably, HDGF is highly expressed in tumor cells, where HDGF acts as a mitogen, stimulating proliferation and contributing to tumor growth. HDGF expression is particularly elevated during vascular injury, highlighting HDGF importance in regenerative processes. Understanding HDGF localization and function is essential for elucidating HDGF role in both normal physiology and pathological conditions, making HDGF (E-7) antibody a valuable tool for researchers studying these processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

HDGF Antibody (E-7) References:

1. Nuclear targeting is required for hepatoma-derived growth factor-stimulated mitogenesis in vascular smooth muscle cells.  |  Everett, AD., et al. 2001. J Biol Chem. 276: 37564-8. PMID: 11481329
2. The family of hepatoma-derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies.  |  Dietz, F., et al. 2002. Biochem J. 366: 491-500. PMID: 12006088
3. Hepatoma-derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferation.  |  Enomoto, H., et al. 2002. Hepatology. 36: 1519-27. PMID: 12447878
4. Hepatoma derived growth factor is a nuclear targeted mitogen.  |  Everett, AD. and Bushweller, J. 2003. Curr Drug Targets. 4: 367-71. PMID: 12816346
5. Functional proteomic analysis of melanoma progression.  |  Bernard, K., et al. 2003. Cancer Res. 63: 6716-25. PMID: 14583466
6. Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factor.  |  Okuda, Y., et al. 2003. Cancer Sci. 94: 1034-41. PMID: 14662017
7. Hepatoma derived growth factor (HDGF) dynamics in ovarian cancer cells.  |  Giri, K., et al. 2016. Apoptosis. 21: 329-39. PMID: 26612514
8. Down-regulation of HDGF Inhibits the Growth of Hepatocellular Carcinoma Cells In Vitro and In Vivo.  |  Enomoto, H., et al. 2015. Anticancer Res. 35: 6475-9. PMID: 26637859
9. METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance.  |  Wang, Q., et al. 2020. Gut. 69: 1193-1205. PMID: 31582403
10. Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis.  |  Lin, YW., et al. 2019. BMC Cancer. 19: 1083. PMID: 31711427
11. Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis.  |  Fazio, M., et al. 2021. Pigment Cell Melanoma Res. 34: 641-647. PMID: 33064882
12. Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway.  |  Qiu, L., et al. 2021. J Transl Med. 19: 344. PMID: 34376200

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HDGF Antibody (E-7) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-HDGF Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HDGF Antibody (E-7) Specifications

Alternate Product Name: HDGF

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 209-240

Epitope Target: HDGF

Epitope Species: human

Product Reactivity/Detection: HDGF

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for HDGF Antibody (E-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin