Histone Deacetylase 3 (HDAC3) Antibody (1): sc-130319

HDAC3 Antibody (1) is a mouse monoclonal IgG1 antibody that detects HDAC3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). HDAC3, or histone deacetylase 3, plays a crucial role in the regulation of gene expression by removing acetyl groups from histones, leading to chromatin condensation and transcriptional repression. This function is vital for maintaining cellular homeostasis and regulating various biological processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of HDAC3 has been implicated in several diseases, including cancer and neurodegenerative disorders, making HDAC3 an important target for therapeutic intervention. HDAC3 is predominantly located in the nucleus, where HDAC3 interacts with various transcription factors and co-repressors to modulate gene expression. Understanding the dynamics of HDAC3 and its interactions can provide insights into the mechanisms of transcriptional regulation and the potential for developing targeted therapies. Anti-HDAC3 antibody (1) is an essential tool for researchers investigating the role of histone deacetylation in gene regulation and its implications in disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Histone Deacetylase 3 (HDAC3) Antibody (1) References:

1. Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation.  |  Zhang, HL., et al. 2022. Adv Sci (Weinh). 9: e2103887. PMID: 35187863
2. Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity.  |  Eshleman, EM., et al. 2023. J Clin Invest. 133: PMID: 36602872
3. The role of HDAC3 and its inhibitors in regulation of oxidative stress and chronic diseases.  |  He, R., et al. 2023. Cell Death Discov. 9: 131. PMID: 37072432
4. The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG.  |  Kugler, E., et al. 2023. Nat Commun. 14: 5871. PMID: 37735473
5. HDAC3 Contributes to Ischemic Stroke by Regulating Interferon Pathway.  |  Wang, J., et al. 2023. J Integr Neurosci. 22: 156. PMID: 38176919
6. HDAC3 promotes Sertoli cell maturation and maintains the blood-testis barrier dynamics.  |  Liu, M., et al. 2024. FASEB J. 38: e23526. PMID: 38430456
7. Glucose regulation of adipose tissue browning by CBP/p300- and HDAC3-mediated reversible acetylation of CREBZF.  |  Cui, A., et al. 2024. Proc Natl Acad Sci U S A. 121: e2318935121. PMID: 38588421
8. Endocardial HDAC3 is required for myocardial trabeculation.  |  Jang, J., et al. 2024. Nat Commun. 15: 4166. PMID: 38755146
9. Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3.  |  Fu, B., et al. 2024. Bone Res. 12: 32. PMID: 38789434
10. Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury.  |  Shahror, RA., et al. 2024. J Neuroinflammation. 21: 170. PMID: 38997746

The preferred Histone Deacetylase 3 (HDAC3) antibody is Histone Deacetylase 3 (HDAC3) Antibody (A-3): sc-376957.