Histone Deacetylase 3 (HDAC3) Antibody (A-3): sc-376957

HDAC3 Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects HDAC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HDAC3 Antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HDAC3 plays a crucial role in gene expression regulation through its function as a histone deacetylase, which removes acetyl groups from lysine residues on histones, leading to chromatin condensation and transcriptional repression. This process is vital for maintaining cellular homeostasis and regulating developmental processes, as aberrant HDAC3 activity has been implicated in various diseases, including cancer and neurodegenerative disorders. Additionally, HDAC3 interacts with several key proteins, such as nuclear receptor corepressors and transcription factors, which further underscores its importance in modulating transcriptional responses to various stimuli. Using anti-HDAC3 antibody (A-3) in research can provide valuable insights into gene regulation mechanisms and potential therapeutic targets for diseases associated with dysregulated histone acetylation.

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Histone Deacetylase 3 (HDAC3) Antibody (A-3) References:

1. Targeting HDAC3 to overcome the resistance to ATRA or arsenic in acute promyelocytic leukemia through ubiquitination and degradation of PML-RARα.  |  Dai, B., et al. 2023. Cell Death Differ. 30: 1320-1333. PMID: 36894687
2. HDAC3 Inhibition Promotes Antitumor Immunity by Enhancing CXCL10-Mediated Chemotaxis and Recruiting of Immune Cells.  |  Li, L., et al. 2023. Cancer Immunol Res. 11: 657-673. PMID: 36898011
3. Macrophagic HDAC3 inhibition ameliorates Dextran Sulfate Sodium induced inflammatory bowel disease through GBP5-NLRP3 pathway.  |  Che, N., et al. 2024. Int J Med Sci. 21: 1385-1398. PMID: 38903915
4. Nucleosome structural changes due to acetylation.  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
5. A positive role for histone acetylation in transcription factor access to nucleosomal DNA.  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
6. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
7. Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.  |  Brownell, JE., et al. 1996. Cell. 84: 843-51. PMID: 8601308
8. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.  |  Taunton, J., et al. 1996. Science. 272: 408-11. PMID: 8602529
9. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.  |  Yang, XJ., et al. 1996. Nature. 382: 319-24. PMID: 8684459
10. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.  |  Yang, WM., et al. 1996. Proc Natl Acad Sci U S A. 93: 12845-50. PMID: 8917507
11. Identification of mouse histone deacetylase 1 as a growth factor-inducible gene.  |  Bartl, S., et al. 1997. Mol Cell Biol. 17: 5033-43. PMID: 9271381
12. Characterization of a human RPD3 ortholog, HDAC3.  |  Emiliani, S., et al. 1998. Proc Natl Acad Sci U S A. 95: 2795-800. PMID: 9501169

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 3 (HDAC3) Antibody (A-3) has 33 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 3 (HDAC3) Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 3 (HDAC3) Antibody (A-3) Specifications

Alternate Product Name: HDAC3

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-29

Epitope Target: HDAC3

Epitope Species: human

Product Reactivity/Detection: HDAC3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 33 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 3 (HDAC3) Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent