Histone Deacetylase 11 (HDAC11) Antibody (C-5): sc-390737

HDAC11 Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody developed against the first 300 amino acids at the N-terminus of the human HDAC11 protein, demonstrating robust reactivity in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) assays. HDAC11, also called HD11, is the sole member of class IV histone deacetylases and plays a pivotal role in the regulation of gene expression by removing acetyl groups from histone proteins, leading to chromatin condensation and transcriptional repression. This enzymatic activity is crucial for various cellular processes, including differentiation, proliferation, and apoptosis, making HDAC11 a key player in maintaining cellular homeostasis and epigenetic regulation. Unlike other HDAC classes, HDAC11 possesses unique structural features that confer specific regulatory functions, including involvement in metabolic pathways and immune response modulation. HDAC11 expression levels are high in vital tissues such as the kidney, heart, brain, skeletal muscle, and testis, where HDAC11 influences tissue-specific gene expression and cellular functions. Localizing predominantly within the nucleus, HDAC11 interacts with various transcription factors and co-repressors to fine-tune gene expression patterns essential for normal development and disease progression. anti-HDAC11 antibody (C-5) is available in both non-conjugated form and multiple conjugated variants, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® conjugates, providing versatile options for a wide range of research applications aimed at elucidating the complex roles of HDAC11 in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Histone Deacetylase 11 (HDAC11) Antibody (C-5) References:

1. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.  |  Gao, L., et al. 2002. J Biol Chem. 277: 25748-55. PMID: 11948178
2. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.  |  Gregoretti, IV., et al. 2004. J Mol Biol. 338: 17-31. PMID: 15050820
3. Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.  |  Bradbury, CA., et al. 2005. Leukemia. 19: 1751-9. PMID: 16121216
4. Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene.  |  Voelter-Mahlknecht, S., et al. 2005. Int J Mol Med. 16: 589-98. PMID: 16142391
5. Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours.  |  Lindberg, D., et al. 2007. Clin Endocrinol (Oxf). 66: 110-4. PMID: 17201809

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 11 (HDAC11) Antibody (C-5) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 11 (HDAC11) Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 11 (HDAC11) Antibody (C-5) Specifications

Alternate Product Name: HDAC11

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: HDAC11

Epitope Species: human

Product Reactivity/Detection: HDAC11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 11 (HDAC11) Antibody (C-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin