HBP1 Antibody (A-5): sc-376831

HBP1 Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects HBP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HBP1, a member of the high mobility group (HMG) family of transcription factors, plays a crucial role in regulating cell cycle progression and differentiation. HBP1 is characterized by the presence of a conserved HMG box motif that facilitates DNA binding, allowing HBP1 to interact with key tumor suppressor proteins like Rb and p130 to initiate cell cycle arrest. This arrest is essential for terminal cell differentiation, as cell cycle arrest sets the stage for the expression of tissue-specific markers. Notably, HBP1′s continued activity can inhibit the expression of these markers by associating with MyoD proteins, which are vital for muscle cell differentiation. The interplay between HBP1 and the MyoD family, which includes Myf5, MyoD, and myogenin, is critical for the development of specific cell phenotypes, as the progression of terminal differentiation relies on a decrease in HBP1 activity coupled with the activation of MyoD-induced gene transcription. Anti-HBP1 antibody (A-5) serves as a valuable tool for studying the intricate mechanisms of cell differentiation and the regulation of gene expression in human tissues.

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HBP1 Antibody (A-5) References:

1. The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppression.  |  Yee, AS., et al. 2004. Gene. 336: 1-13. PMID: 15225871
2. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.  |  Wang, W., et al. 2012. Nucleic Acids Res. 40: 981-95. PMID: 21967847
3. The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.  |  Coomans de Brachène, A., et al. 2014. Biochem J. 460: 25-34. PMID: 24762137
4. High mobility group box transcription factor 1 (HBP1) from Lampetra japonica affects cell cycle regulation.  |  Song, X., et al. 2018. Dev Growth Differ. 60: 146-157. PMID: 29520767
5. Regulatory role of transcription factor HBP1 in anticancer efficacy of EGFR inhibitor erlotinib in HNSCC.  |  Chan, CY., et al. 2020. Head Neck. 42: 2958-2967. PMID: 32677158
6. HBP1 deficiency protects against stress-induced premature senescence of nucleus pulposus.  |  Liu, W., et al. 2020. Eur Rev Med Pharmacol Sci. 24: 8685-8693. PMID: 32964956
7. microRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic fatty liver disease by targeting HBP1.  |  Chu, K. and Gu, J. 2022. Immunopharmacol Immunotoxicol. 44: 993-1003. PMID: 35848933
8. HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene.  |  Cheng, Y., et al. 2022. Aging (Albany NY). 14: 8763-8782. PMID: 36326689
9. HBP1 promotes chicken preadipocyte proliferation via directly repressing SOCS3 transcription.  |  Chen, H., et al. 2024. Int J Biol Macromol. 256: 128414. PMID: 38029903
10. Regulation of differentiation by HBP1, a target of the retinoblastoma protein.  |  Shih, HH., et al. 1998. Mol Cell Biol. 18: 4732-43. PMID: 9671483

The preferred HBP1 antibody is HBP1 Antibody (G-8): sc-515281.