GTPBP9 Antibody (G-6): sc-393946
- GTPBP9 Antibody (G-6) is a mouse monoclonal IgG1 κ GTPBP9 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 60-83 near the N-terminus of GTPBP9 of human origin
- GTPBP9 Antibody (G-6) is recommended for detection of GTPBP9 isoforms 1 and 3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-GTPBP9 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GTPBP9 Antibody (G-6) for WB applications. These reagents are now offered in bundles with GTPBP9 Antibody (G-6) (see ordering information below).
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GTPBP9 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects GTPBP9 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GTPBP9 (G-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GTP-binding protein 9 (GTPBP9), also known as Obg-like ATPase 1 (OLA1), is a 396 amino acid protein that belongs to the Obg-related GTPase family within the translation factors (TRAFAC) class. GTPBP9 plays a crucial role in cellular processes, particularly in regulating translation and ribosome biogenesis, which are essential for protein synthesis and cellular function. GTPBP9 exhibits a preference for binding ATP over GTP, with GTP binding occurring only at high nucleotide concentrations, a characteristic significant for regulatory functions. GTPBP9 contains a C-terminal TGS domain that binds to ligands and an N-terminal G domain that binds nucleotides, and expresses as three isoforms produced by alternative splicing. Understanding GTPBP9 function is vital, as dysregulation may have implications in various biological processes and diseases, including cancer, where protein synthesis irregularities are often observed.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GTPBP9 Antibody (G-6) References:
- The guanine nucleotide-binding switch in three dimensions. | Vetter, IR. and Wittinghofer, A. 2001. Science. 294: 1299-304. PMID: 11701921
- Classification and evolution of P-loop GTPases and related ATPases. | Leipe, DD., et al. 2002. J Mol Biol. 317: 41-72. PMID: 11916378
- Function of the universally conserved bacterial GTPases. | Caldon, CE. and March, PE. 2003. Curr Opin Microbiol. 6: 135-9. PMID: 12732302
- Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid. | Teplyakov, A., et al. 2003. J Bacteriol. 185: 4031-7. PMID: 12837776
- Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. | Brown, ED. 2005. Biochem Cell Biol. 83: 738-46. PMID: 16333325
- Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins. | Koller-Eichhorn, R., et al. 2007. J Biol Chem. 282: 19928-37. PMID: 17430889
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GTPBP9 Antibody (G-6) | sc-393946 | 200 µg/ml | $316.00 | |||
GTPBP9 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-527722 | 200 µg Ab; 10 µg BP | $354.00 | |||
GTPBP9 Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-533095 | 200 µg Ab; 20 µg BP | $354.00 | |||
GTPBP9 Antibody (G-6) AC | sc-393946 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GTPBP9 Antibody (G-6) HRP | sc-393946 HRP | 200 µg/ml | $316.00 | |||
GTPBP9 Antibody (G-6) FITC | sc-393946 FITC | 200 µg/ml | $330.00 | |||
GTPBP9 Antibody (G-6) PE | sc-393946 PE | 200 µg/ml | $343.00 | |||
GTPBP9 Antibody (G-6) Alexa Fluor® 488 | sc-393946 AF488 | 200 µg/ml | $357.00 | |||
GTPBP9 Antibody (G-6) Alexa Fluor® 546 | sc-393946 AF546 | 200 µg/ml | $357.00 | |||
GTPBP9 Antibody (G-6) Alexa Fluor® 594 | sc-393946 AF594 | 200 µg/ml | $357.00 | |||
GTPBP9 Antibody (G-6) Alexa Fluor® 647 | sc-393946 AF647 | 200 µg/ml | $357.00 | |||
GTPBP9 Antibody (G-6) Alexa Fluor® 680 | sc-393946 AF680 | 200 µg/ml | $357.00 | |||
GTPBP9 Antibody (G-6) Alexa Fluor® 790 | sc-393946 AF790 | 200 µg/ml | $357.00 | |||
GTPBP9 (G-6) Neutralizing Peptide | sc-393946 P | 100 µg/0.5 ml | $68.00 |