GTPBP9 Inhibitors
OLA1 (Obg-like ATPase 1) is a multifunctional protein involved in various cellular processes, including protein folding, ribosome biogenesis, mitochondrial functions, and cellular stress response. It belongs to the Obg family of GTPases and plays a crucial role in modulating cellular functions by interacting with different partners and coordinating essential processes. OLA1's signaling primarily revolves around its nucleotide binding and hydrolysis properties, where it switches between GTP-bound active and GDP-bound inactive states to regulate its interactions with various cellular components. It interacts with ribosomal proteins, chaperones, and factors involved in protein synthesis and folding, contributing to proper cellular function and response to stress conditions.
OLA1 inhibitors are compounds designed to target the ATPase activity or interactions of OLA1, aiming to modulate its functions and downstream cellular processes. These inhibitors hold the potential to affect protein folding, ribosome biogenesis, and other OLA1-related functions. By inhibiting OLA1, researchers can investigate its roles in cellular mechanisms and evaluate its impact on cellular stress responses, protein homeostasis, and other processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is a natural compound that targets heat shock protein 90 (HSP90), a chaperone protein involved in protein folding and stability. By binding to HSP90, Geldanamycin disrupts its function, leading to the destabilization and degradation of client proteins. This compound indirectly affects OLA1-related processes by influencing protein folding and quality control mechanisms within the cell. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $92.00 $333.00 | 13 | |
Radicicol is another natural compound that targets HSP90. Similar to Geldanamycin, it binds to HSP90 and disrupts its chaperone function, resulting in the degradation of client proteins. Radicicol's impact on HSP90-related pathways may have downstream effects on cellular processes involving OLA1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that blocks the activity of the proteasome complex responsible for degrading proteins. By inhibiting the proteasome, MG-132 leads to the accumulation of ubiquitinated proteins and interferes with protein degradation pathways. While its direct impact on OLA1 is not well-established, alterations in proteasome-mediated degradation could indirectly influence OLA1-related functions. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is another proteasome inhibitor commonly used in cancer therapy. It disrupts proteasome activity, leading to the buildup of misfolded or ubiquitinated proteins. While its direct effects on OLA1 are not known, the disruption of proteasome-mediated protein degradation might indirectly impact OLA1's roles in protein quality control. | ||||||