GSTT2 Antibody (D-1): sc-514667
- GSTT2 Antibody (D-1) is a mouse monoclonal IgG2a κ GSTT2 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 145-168 within an internal region of GSTT2 of human origin
- GSTT2 Antibody (D-1) is recommended for detection of GSTT2 and GSTT2B of human origin, and GSTT2 of mouse and rat origin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GSTT2 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GSTT2 Antibody (D-1) for WB applications. These reagents are now offered in bundles with GSTT2 Antibody (D-1) (see ordering information below).
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GSTT2 Antibody (D-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects GSTT2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GSTT2 (D-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GSTT2 protein, also known as glutathione S-transferase theta-2, plays a crucial role in detoxifying harmful compounds by conjugating reduced glutathione to hydrophobic electrophiles, thereby facilitating their excretion from the cell. This enzymatic activity is vital for cellular protection against oxidative stress and the accumulation of toxic metabolites, which can lead to cellular damage and disease. GSTT2 is a 244 amino acid enzyme that exists as a homodimer in the cytoplasm and is expressed at low levels in the liver and lung, highlighting its importance in organ-specific detoxification processes. As a member of the GST superfamily, GSTT2 contains both GST C-terminal and N-terminal domains, and its gene is located on human chromosome 22, underscoring its evolutionary significance and potential as a therapeutic target in conditions associated with oxidative stress.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GSTT2 Antibody (D-1) References:
- Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. | Sprenger, R., et al. 2000. Pharmacogenetics. 10: 557-65. PMID: 10975610
- Determination of blood total, reduced, and oxidized glutathione in pediatric subjects. | Pastore, A., et al. 2001. Clin Chem. 47: 1467-9. PMID: 11468240
- Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate. | Hussey, AJ. and Hayes, JD. 1992. Biochem J. 286 (Pt 3): 929-35. PMID: 1417752
- The changing faces of glutathione, a cellular protagonist. | Pompella, A., et al. 2003. Biochem Pharmacol. 66: 1499-503. PMID: 14555227
- Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. | Tan, KL., et al. 1995. Genomics. 25: 381-7. PMID: 7789971
- The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. | Mainwaring, GW., et al. 1996. Biochem J. 318 (Pt 1): 297-303. PMID: 8761485
- Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site. | Rossjohn, J., et al. 1998. Structure. 6: 309-22. PMID: 9551553
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSTT2 Antibody (D-1) | sc-514667 | 200 µg/ml | $316.00 | |||
GSTT2 Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-531186 | 200 µg Ab; 10 µg BP | $354.00 | |||
GSTT2 Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-524805 | 200 µg Ab, 40 µg BP | $354.00 | |||
GSTT2 Antibody (D-1): m-IgG2a BP-HRP Bundle | sc-547717 | 200 µg Ab; 10 µg BP | $354.00 | |||
GSTT2 Antibody (D-1) AC | sc-514667 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GSTT2 Antibody (D-1) HRP | sc-514667 HRP | 200 µg/ml | $316.00 | |||
GSTT2 Antibody (D-1) FITC | sc-514667 FITC | 200 µg/ml | $330.00 | |||
GSTT2 Antibody (D-1) PE | sc-514667 PE | 200 µg/ml | $343.00 | |||
GSTT2 Antibody (D-1) Alexa Fluor® 488 | sc-514667 AF488 | 200 µg/ml | $357.00 | |||
GSTT2 Antibody (D-1) Alexa Fluor® 546 | sc-514667 AF546 | 200 µg/ml | $357.00 | |||
GSTT2 Antibody (D-1) Alexa Fluor® 594 | sc-514667 AF594 | 200 µg/ml | $357.00 | |||
GSTT2 Antibody (D-1) Alexa Fluor® 647 | sc-514667 AF647 | 200 µg/ml | $357.00 | |||
GSTT2 Antibody (D-1) Alexa Fluor® 680 | sc-514667 AF680 | 200 µg/ml | $357.00 | |||
GSTT2 Antibody (D-1) Alexa Fluor® 790 | sc-514667 AF790 | 200 µg/ml | $357.00 | |||
GSTT2 (D-1) Neutralizing Peptide | sc-514667 P | 100 µg/0.5 ml | $68.00 |