GSK3 beta Antibody (11B9): sc-81462

GSK-3β Antibody (11B9) is a mouse monoclonal IgG1 that specifically detects glycogen synthase kinase 3 beta (GSK-3β) from mouse, rat, human, and other species, including canine, via western blotting (WB) and immunoprecipitation (IP). GSK-3β is a serine/threonine kinase that plays a pivotal role in regulating multiple cellular processes, including glycogen metabolism, cell proliferation, and apoptosis. One key aspect of GSK-3β regulation is its post-translational modifications, particularly phosphorylation. Phosphorylation at specific serine and tyrosine residues modulates GSK-3β activity, for instance, phosphorylation at Ser9 inhibits its kinase activity, while phosphorylation at Tyr216 enhances activity. These modifications are crucial for controlling GSK-3β′s interactions with substrates and involvement in signaling pathways. Dysregulation of GSK-3β′s post-translational modifications has been linked to various diseases, including neurodegenerative disorders like Alzheimer′s, where abnormal phosphorylation of GSK-3β targets such as the Tau protein contributes to pathological conditions. Understanding how post-translational modifications impact GSK-3β′s function is essential for gaining insights into regulatory mechanisms and potential role in disease, making anti-GSK-3β antibody (11B9) a valuable tool for researchers studying GSK-3β in different biological contexts.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GSK3 beta Antibody (11B9) has 83 citations in a variety of scientific publications.

Primary antibodies like Anti-GSK3 beta Antibody (11B9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GSK3 beta Antibody (11B9) Specifications

Alternate Product Name: GSK3

Product Clone Name: 11B9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: GSK-3β

Epitope Species: human

Product Reactivity/Detection: GSK-3β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose

Research Citations: 83 citations in various scientific publications

Available Conjugates/Forms for GSK3 beta Antibody (11B9): N/A

The preferred GSK3 alpha/beta antibody is GSK3 alpha/beta Antibody (0011-A): sc-7291.