GSK-3α Antibody (9D5G1): sc-81166
- GSK-3α Antibody (9D5G1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 84-150 of GSK-3α of human origin
- recommended for detection of GSK-3α of mouse, rat and human origin by WB and IP
- See GSK3 alpha/beta (0011-A): sc-7291 for GSK-3α antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GSK-3α Antibody (9D5G1). This work is in progress.
GSK-3α Antibody (9D5G1) is a mouse monoclonal IgG1 antibody that detects glycogen synthase kinase 3 alpha (GSK-3α) in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). GSK-3α is a crucial serine/threonine kinase that plays a significant role in various cellular processes, including glycogen metabolism and cell signaling pathways. GSK-3α (9D5G1) antibody enables detection of GSK-3α′s involvement in regulating Tau protein, which stabilizes microtubules in neurons. GSK-3α-mediated phosphorylation of Tau is particularly important because hyper-phosphorylated Tau forms paired helical filaments, a hallmark of neurofibrillary tangles found in Alzheimer′s disease. This aberrant phosphorylation disrupts normal microtubule dynamics, leading to neurodegeneration. GSK-3α′s ability to modulate Tau phosphorylation highlights its potential as a therapeutic target in Alzheimer′s disease and other tauopathies. Anti-GSK-3α antibody (9D5G1) provides a valuable tool for researchers investigating signaling pathways involving GSK-3α and its implications in neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GSK-3α Antibody (9D5G1) References:
- Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. | Doble, BW., et al. 2007. Dev Cell. 12: 957-71. PMID: 17543867
- Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. | Matsuda, T., et al. 2008. Proc Natl Acad Sci U S A. 105: 20900-5. PMID: 19106302
- GSK-3α/β kinases and amyloid production in vivo. | Jaworski, T., et al. 2011. Nature. 480: E4-5; discussion E6. PMID: 22158250
- Identification of porcine glycogen synthase kinase 3α (GSK-3α) gene and its association with carcass traits. | Wang, L., et al. 2013. Mol Cell Biochem. 377: 65-73. PMID: 23358925
- GSK-3α promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-κB. | Bang, D., et al. 2013. Cancer Discov. 3: 690-703. PMID: 23547054
- Inositol synthesis regulates the activation of GSK-3α in neuronal cells. | Ye, C. and Greenberg, ML. 2015. J Neurochem. 133: 273-83. PMID: 25345501
- GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer. | Park, SA., et al. 2016. PLoS One. 11: e0153075. PMID: 27049759
- GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer. | Silva-García, O., et al. 2020. Biomolecules. 10: PMID: 33339170
- Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3β rather than GSK-3α-dependent melanogenesis in murine melanoma cells. | Jia, Q., et al. 2022. J Dermatol Sci. 106: 170-180. PMID: 35641396
- GSK3α Regulates Temporally Dynamic Changes in Ribosomal Proteins upon Amino Acid Starvation in Cancer Cells. | Loxha, L., et al. 2023. Int J Mol Sci. 24: PMID: 37686063
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3α Antibody (9D5G1) | sc-81166 | 200 µg/ml | $322.00 |