GRWD1 Antibody (D-1): sc-514042
- GRWD1 Antibody (D-1) is a mouse monoclonal IgG1 κ GRWD1 antibody provided at 200 µg/ml
- raised against amino acids 139-318 mapping within an internal region of GRWD1 of human origin
- GRWD1 Antibody (D-1) is recommended for detection of GRWD1 of human and, to a lesser extent, mouse, rat origin by WB, IP, IF and ELISA
- Anti-GRWD1 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRWD1 Antibody (D-1) for WB applications. These reagents are now offered in bundles with GRWD1 Antibody (D-1) (see ordering information below).
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SEE ALSO...
GRWD1 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects GRWD1 protein of human origin, with some reactivity to mouse and rat, by applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-GRWD1 antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GRWD1, also known as glutamate-rich WD repeat-containing protein 1, WDR28, or KIAA1942, consists of 446 amino acids and features five WD repeats, which are critical for protein-protein interactions. GRWD1 is primarily localized in the nucleus and is a key component of the 50S and 80S preribosomal complexes, suggesting a significant role in ribosome biogenesis, a vital process for cellular function and protein synthesis. The gene encoding GRWD1 is located on human chromosome 19q13.33, a region known for its high gene density and association with various genetic disorders, including Peutz-Jeghers syndrome and insulin-dependent diabetes. The importance of GRWD1 in ribosome assembly underscores its potential impact on cellular growth and proliferation, making GRWD1 a valuable target for research in cellular biology and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GRWD1 Antibody (D-1) References:
- C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers. | Wang, L., et al. 2000. Clin Cancer Res. 6: 2988-93. PMID: 10955775
- The genomic context of natural killer receptor extended gene families. | Trowsdale, J., et al. 2001. Immunol Rev. 181: 20-38. PMID: 11513141
- Complete germline deletion of the STK11 gene in a family with Peutz-Jeghers syndrome. | Le Meur, N., et al. 2004. Eur J Hum Genet. 12: 415-8. PMID: 14970844
- Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q. | Leeb, T. and Müller, M. 2004. Gene. 343: 239-44. PMID: 15588578
- The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis. | Gratenstein, K., et al. 2005. Genomics. 85: 762-73. PMID: 15885502
- The extended human leukocyte receptor complex: diverse ways of modulating immune responses. | Barrow, AD. and Trowsdale, J. 2008. Immunol Rev. 224: 98-123. PMID: 18759923
- The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family. | Teglund, S., et al. 1994. Genomics. 23: 669-84. PMID: 7851896
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRWD1 Antibody (D-1) | sc-514042 | 200 µg/ml | $322.00 | |||
GRWD1 Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-531010 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRWD1 Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-524583 | 200 µg Ab, 40 µg BP | $361.00 | |||
GRWD1 Antibody (D-1): m-IgG1 BP-HRP Bundle | sc-544358 | 200 µg Ab; 20 µg BP | $361.00 | |||
GRWD1 Antibody (D-1) AC | sc-514042 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GRWD1 Antibody (D-1) HRP | sc-514042 HRP | 200 µg/ml | $322.00 | |||
GRWD1 Antibody (D-1) FITC | sc-514042 FITC | 200 µg/ml | $336.00 | |||
GRWD1 Antibody (D-1) PE | sc-514042 PE | 200 µg/ml | $349.00 | |||
GRWD1 Antibody (D-1) Alexa Fluor® 488 | sc-514042 AF488 | 200 µg/ml | $364.00 | |||
GRWD1 Antibody (D-1) Alexa Fluor® 546 | sc-514042 AF546 | 200 µg/ml | $364.00 | |||
GRWD1 Antibody (D-1) Alexa Fluor® 594 | sc-514042 AF594 | 200 µg/ml | $364.00 | |||
GRWD1 Antibody (D-1) Alexa Fluor® 647 | sc-514042 AF647 | 200 µg/ml | $364.00 | |||
GRWD1 Antibody (D-1) Alexa Fluor® 680 | sc-514042 AF680 | 200 µg/ml | $364.00 | |||
GRWD1 Antibody (D-1) Alexa Fluor® 790 | sc-514042 AF790 | 200 µg/ml | $364.00 |