group V PLA2 Antibody (C-4): sc-393606
- group V PLA2 Antibody (C-4) is a mouse monoclonal IgG1 κ group V PLA2 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-137 representing full length group V PLA2 of mouse origin
- group V PLA2 Antibody (C-4) is recommended for detection of group V PLA2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-group V PLA2 Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for group V PLA2 Antibody (C-4) for WB and IHC(P) applications. These reagents are now offered in bundles with group V PLA2 Antibody (C-4) (see ordering information below).
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Group V PLA2 Antibody (C-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects group V PLA2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-group V PLA2 antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Group V phospholipase A2 (PLA2) protein plays a crucial role in lipid metabolism by hydrolyzing the sn-2-acyl ester bond in glycerophospholipids, which leads to the release of free fatty acids, including arachidonic acid. This process is significant because arachidonic acid serves as a precursor for the synthesis of various eicosanoids, such as prostaglandins and leukotrienes, which are key mediators in inflammatory responses. Group V PLA2′s ability to modulate bioactive lipid levels highlights its importance in both physiological and pathological processes, including inflammation and immune responses. Group V PLA2′s calcium-dependent activity and presence in both intracellular and extracellular environments further underscore its versatile role in cellular signaling and membrane dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
group V PLA2 Antibody (C-4) References:
- Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. | Wooton-Kee, CR., et al. 2004. Arterioscler Thromb Vasc Biol. 24: 762-7. PMID: 14962950
- Regulation of extracellular phospholipase A2 activity: implications for inflammatory diseases. | Mukherjee, AB., et al. 1992. DNA Cell Biol. 11: 233-43. PMID: 1567556
- Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2. | Sharp, JD., et al. 1991. J Biol Chem. 266: 14850-3. PMID: 1869522
- A novel bifunctional mechanism of surface recognition by phospholipase A2. | Heinrikson, RL. and Kézdy, FJ. 1990. Adv Exp Med Biol. 279: 37-47. PMID: 2096699
- Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937. | Clark, JD., et al. 1990. Proc Natl Acad Sci U S A. 87: 7708-12. PMID: 2217203
- Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus. A new classification of phospholipases A2 based upon structural determinants. | Heinrikson, RL., et al. 1977. J Biol Chem. 252: 4913-21. PMID: 873920
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
group V PLA2 Antibody (C-4) | sc-393606 | 200 µg/ml | $322.00 | |||
group V PLA2 Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-527698 | 200 µg Ab; 10 µg BP | $361.00 | |||
group V PLA2 Antibody (C-4): m-IgG1 BP-HRP Bundle | sc-533071 | 200 µg Ab; 20 µg BP | $361.00 | |||
group V PLA2 Antibody (C-4) AC | sc-393606 AC | 500 µg/ml, 25% agarose | $424.00 | |||
group V PLA2 Antibody (C-4) HRP | sc-393606 HRP | 200 µg/ml | $322.00 | |||
group V PLA2 Antibody (C-4) FITC | sc-393606 FITC | 200 µg/ml | $336.00 | |||
group V PLA2 Antibody (C-4) PE | sc-393606 PE | 200 µg/ml | $349.00 | |||
group V PLA2 Antibody (C-4) Alexa Fluor® 488 | sc-393606 AF488 | 200 µg/ml | $364.00 | |||
group V PLA2 Antibody (C-4) Alexa Fluor® 546 | sc-393606 AF546 | 200 µg/ml | $364.00 | |||
group V PLA2 Antibody (C-4) Alexa Fluor® 594 | sc-393606 AF594 | 200 µg/ml | $364.00 | |||
group V PLA2 Antibody (C-4) Alexa Fluor® 647 | sc-393606 AF647 | 200 µg/ml | $364.00 | |||
group V PLA2 Antibody (C-4) Alexa Fluor® 680 | sc-393606 AF680 | 200 µg/ml | $364.00 | |||
group V PLA2 Antibody (C-4) Alexa Fluor® 790 | sc-393606 AF790 | 200 µg/ml | $364.00 |