GRK 2 Antibody (F-9): sc-166284
- GRK 2 Antibody (F-9) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 661-699 near the C-terminus of GRK 2 of human origin
- recommended for detection of GRK 2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and porcine
- See GRK 2 (C-9): sc-13143 for GRK 2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRK 2 Antibody (F-9) for WB applications. These reagents are now offered in bundles with GRK 2 Antibody (F-9) (see ordering information below).
GRK 2 Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects GRK 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRK 2, a member of the G protein-coupled receptor kinase family, plays a crucial role in the regulation of G protein-coupled receptor signaling by phosphorylating activated receptors, which leads to their desensitization and internalization. This process is vital for maintaining cellular responsiveness to external signals, as it prevents overstimulation and allows for the fine-tuning of physiological responses. GRK 2 is predominantly located in the cytoplasm and can translocate to the plasma membrane upon receptor activation, highlighting its dynamic role in signal transduction. The ability of GRK 2 to interact with various proteins, including β-arrestins, further underscores its importance in modulating receptor activity and downstream signaling pathways. Using anti-GRK 2 antibody (F-9), researchers can gain insights into the mechanisms of receptor desensitization and the broader implications for cellular signaling in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRK 2 Antibody (F-9) | sc-166284 | 200 µg/ml | $322.00 | |||
GRK 2 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-537469 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRK 2 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-534745 | 200 µg Ab; 40 µg BP | $361.00 | |||
GRK 2 Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-545197 | 200 µg Ab; 20 µg BP | $361.00 | |||
GRK 2 (F-9) Neutralizing Peptide | sc-166284 P | 100 µg/0.5 ml | $69.00 |