GRK 2 Antibody (F-9): sc-166284
- GRK 2 Antibody (F-9) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 661-699 near the C-terminus of GRK 2 of human origin
- recommended for detection of GRK 2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and porcine
- See GRK 2 (C-9): sc-13143 for GRK 2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRK 2 Antibody (F-9) for WB applications. These reagents are now offered in bundles with GRK 2 Antibody (F-9) (see ordering information below).
GRK 2 Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects GRK 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRK 2, a member of the G protein-coupled receptor kinase family, plays a crucial role in the regulation of G protein-coupled receptor signaling by phosphorylating activated receptors, which leads to their desensitization and internalization. This process is vital for maintaining cellular responsiveness to external signals, as it prevents overstimulation and allows for the fine-tuning of physiological responses. GRK 2 is predominantly located in the cytoplasm and can translocate to the plasma membrane upon receptor activation, highlighting its dynamic role in signal transduction. The ability of GRK 2 to interact with various proteins, including β-arrestins, further underscores its importance in modulating receptor activity and downstream signaling pathways. Using anti-GRK 2 antibody (F-9), researchers can gain insights into the mechanisms of receptor desensitization and the broader implications for cellular signaling in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
GRK 2 Antibody (F-9) References:
- Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies. | Rudomanova, V. and Blaxall, BC. 2017. Biochim Biophys Acta Mol Basis Dis. 1863: 1883-1892. PMID: 28130200
- G protein-coupled receptor kinase 2 (GRK2) as an integrative signalling node in the regulation of cardiovascular function and metabolic homeostasis. | Mayor, F., et al. 2018. Cell Signal. 41: 25-32. PMID: 28389415
- G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases. | Murga, C., et al. 2019. Front Pharmacol. 10: 112. PMID: 30837878
- Potential Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis. | Kuai, J., et al. 2021. Front Immunol. 12: 698424. PMID: 34335610
- GRK2 regulates group 2 innate lymphoid cell mobilization in sepsis. | Lai, D., et al. 2022. Mol Med. 28: 32. PMID: 35272622
- GRK2 in cardiovascular disease and its potential as a therapeutic target. | Ferrero, KM. and Koch, WJ. 2022. J Mol Cell Cardiol. 172: 14-23. PMID: 35878706
- Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen. | Fu, L., et al. 2023. Am J Physiol Cell Physiol. 324: C505-C516. PMID: 36622065
- GRK2-Targeted Knockdown as Therapy for Multiple System Atrophy. | Lopez-Cuina, M., et al. 2023. Mov Disord. 38: 1336-1340. PMID: 37093618
- GRK2 expression and catalytic activity are essential for vasoconstrictor/ERK-stimulated arterial smooth muscle proliferation. | Alonazi, A., et al. 2023. Biochem Pharmacol. 216: 115795. PMID: 37690571
- Inhibition of GRK2 ameliorates the pristane-induced mouse SLE model by suppressing plasma cells differentiation. | Han, D., et al. 2024. Int Immunopharmacol. 138: 112557. PMID: 38936060
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRK 2 Antibody (F-9) | sc-166284 | 200 µg/ml | $322.00 | |||
GRK 2 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-537469 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRK 2 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-534745 | 200 µg Ab; 40 µg BP | $361.00 | |||
GRK 2 Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-545197 | 200 µg Ab; 20 µg BP | $361.00 | |||
GRK 2 (F-9) Neutralizing Peptide | sc-166284 P | 100 µg/0.5 ml | $69.00 |