GRK 2 Antibody (C-9): sc-13143

GRK 2 Antibody (C-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects GRK 2 protein of mouse, rat, and human origin by WB, IP, IF, and ELISA. GRK 2 Antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, HRP, PE, FITC, and multiple Alexa Fluor® conjugates. GRK 2 protein plays a crucial role in the regulation of G protein-coupled receptor signaling, which is essential for numerous physiological processes, including vision, taste, and neurotransmission. Located primarily in the cytoplasm and membrane of cells, GRK 2 is activated upon receptor stimulation, leading to the phosphorylation of activated receptors. This phosphorylation is vital for the desensitization of receptors, preventing overstimulation and ensuring that cells can respond appropriately to external signals. GRK 2 modulation of receptor activity is particularly important in the context of cardiovascular health, as GRK 2 helps regulate heart rate and contractility. Understanding GRK 2 function and regulation is essential for developing therapeutic strategies targeting various diseases, including heart failure and hypertension.

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GRK 2 Antibody (C-9) References:

1. The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.  |  Lorenz, W., et al. 1991. Proc Natl Acad Sci U S A. 88: 8715-9. PMID: 1656454
2. Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.  |  Benovic, JL., et al. 1991. J Biol Chem. 266: 14939-46. PMID: 1869533
3. Turning off the signal: desensitization of beta-adrenergic receptor function.  |  Hausdorff, WP., et al. 1990. FASEB J. 4: 2881-9. PMID: 2165947
4. GPCR activation and GRK2 assembly by a biased intracellular agonist.  |  Duan, J., et al. 2023. Nature. 620: 676-681. PMID: 37532940
5. GRK2-YAP signaling is implicated in pulmonary arterial hypertension development.  |  Ye, P., et al. 2024. Chin Med J (Engl). 137: 846-858. PMID: 38242702
6. GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.  |  Yang, X., et al. 2024. Acta Pharm Sin B. 14: 241-255. PMID: 38261818
7. GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.  |  Walker, MF., et al. 2024. PLoS Biol. 22: e3002685. PMID: 39138140
8. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.  |  Premont, RT., et al. 1994. J Biol Chem. 269: 6832-41. PMID: 8120045
9. An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.  |  Pei, G., et al. 1994. Proc Natl Acad Sci U S A. 91: 3633-6. PMID: 8170959
10. Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.  |  Inglese, J., et al. 1994. Proc Natl Acad Sci U S A. 91: 3637-41. PMID: 8170960
11. Structure and mechanism of the G protein-coupled receptor kinases.  |  Inglese, J., et al. 1993. J Biol Chem. 268: 23735-8. PMID: 8226899
12. Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.  |  Liggett, SB., et al. 1993. Proc Natl Acad Sci U S A. 90: 3665-9. PMID: 8386380

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GRK 2 Antibody (C-9) has 58 citations in a variety of scientific publications.

Primary antibodies like Anti-GRK 2 Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GRK 2 Antibody (C-9) Specifications

Alternate Product Name: GRK2

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 468-689

Epitope Target: GRK 2

Epitope Species: human

Product Reactivity/Detection: GRK 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 58 citations in various scientific publications

Available Conjugates/Forms for GRK 2 Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin