Grim19 Antibody (C-5): sc-365045
- Grim19 Antibody (C-5) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 62-132 mapping near the C-terminus of Grim19 of human origin
- recommended for detection of Grim19 of human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Grim19 Antibody (C-5) for WB applications. This reagent is now offered in a bundle with Grim19 Antibody (C-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Grim19 Antibody (C-5) is a mouse monoclonal IgG2b antibody that detects Grim19 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Grim19, also known as gene associated with retinoic-interferon-induced mortality 19 protein or cell death-regulatory protein Grim-19, plays a crucial role in cellular processes by functioning as a tumor suppressor. Grim19 (C-5) antibody targets a protein primarily located in the mitochondrion, where Grim19 is integral to the assembly and electron transfer activity of mitochondrial complex I. The localization of Grim19 is significant because Grim19 not only facilitates the transfer of electrons from NADH to the respiratory chain, which is essential for ATP production, but also participates in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway, inducing apoptosis in response to cellular stress signals. Grim19 can translocate to the nucleus upon treatment with interferon or retinoic acid, suggesting a dual role in both mitochondrial function and nuclear signaling. This unique characteristic positions anti-Grim19 antibody (C-5) as an invaluable tool for researchers studying implications in tumor biology and cell death mechanisms.
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Grim19 Antibody (C-5) References:
- Overexpression of GRIM-19 in cancer cells suppresses STAT3-mediated signal transduction and cancer growth. | Okamoto, T., et al. 2010. Mol Cancer Ther. 9: 2333-43. PMID: 20682646
- GRIM-19 mutations fail to inhibit v-Src-induced oncogenesis. | Kalakonda, S., et al. 2014. Oncogene. 33: 3195-204. PMID: 23851499
- Expression of GRIM-19 in missed abortion and possible pathogenesis. | Chen, H., et al. 2015. Fertil Steril. 103: 138-46.e3. PMID: 25455534
- GRIM-19 Restricts HCV Replication by Attenuating Intracellular Lipid Accumulation. | Kim, JH., et al. 2017. Front Microbiol. 8: 576. PMID: 28443075
- Inhibition of miR-423-5p suppressed prostate cancer through targeting GRIM-19. | Lin, H., et al. 2019. Gene. 688: 93-97. PMID: 30415005
- Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2. | Kummari, R., et al. 2021. Biochem J. 478: 1241-1259. PMID: 33650635
- GRIM-19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation. | Kurane, T., et al. 2022. FASEB J. 36: e22096. PMID: 34907600
- Decreased expression of GRIM-19 induces autophagy through the AMPK/ULK1 signaling pathway during adenomyosis†. | Huang, Y., et al. 2022. Biol Reprod. 107: 956-966. PMID: 35908189
- GRIM-19 in asthenozoospermia regulates GC-2 spd cell proliferation, apoptosis and migration. | Li, F., et al. 2023. Sci Rep. 13: 3106. PMID: 36813832
- GRIM-19 deficiency promotes macrophage polarization to the M1 phenotype partly through glycolysis in unexplained recurrent spontaneous abortion†. | Wang, B., et al. 2024. Biol Reprod. 110: 739-749. PMID: 38206868
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Grim19 Antibody (C-5) | sc-365045 | 200 µg/ml | $322.00 | |||
Grim19 Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-535135 | 200 µg Ab; 40 µg BP | $361.00 |