GRB2 Antibody (E-1): sc-17813
- GRB2 Antibody (E-1) is a mouse monoclonal IgG2b κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 148-217 mapping at the C-terminus of GRB2 of human origin
- recommended for detection of GRB2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See GRB2 (C-7): sc-8034 for GRB2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRB2 Antibody (E-1) for WB applications. These reagents are now offered in bundles with GRB2 Antibody (E-1) (see ordering information below).
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GRB2 Antibody (E-1) is a mouse monoclonal IgG2b antibody that detects GRB2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GRB2 antibody (E-1) plays a crucial role in cellular signaling pathways, particularly in the regulation of growth factor-induced activation of Ras proteins, which are pivotal in controlling cell proliferation, differentiation, and survival. GRB2 is primarily located in the cytoplasm and forms complexes with activated receptor molecules, such as the epidermal growth factor receptor (EGFR), and guanine nucleotide exchange factors like SOS1. This localization enables GRB2 to act as a critical adaptor that links receptor activation to downstream signaling cascades, thereby influencing various cellular responses. Additionally, GRB2 is essential during embryogenesis, facilitating the differentiation of endodermal cells and the formation of the epiblast, highlighting its importance in developmental biology. GRB2 (E-1) antibody serves as an invaluable tool for researchers studying these complex signaling pathways and their implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRB2 Antibody (E-1) | sc-17813 | 200 µg/ml | $322.00 | |||
GRB2 Antibody (E-1): m-IgGκ BP-HRP Bundle | sc-533743 | 200 µg Ab; 40 µg BP | $361.00 | |||
GRB2 Antibody (E-1): m-IgG2b BP-HRP Bundle | sc-549236 | 200 µg Ab; 10 µg BP | $361.00 |