GRB2 Antibody (E-1): sc-17813

GRB2 Antibody (E-1) is a mouse monoclonal IgG2b antibody that detects GRB2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GRB2 antibody (E-1) plays a crucial role in cellular signaling pathways, particularly in the regulation of growth factor-induced activation of Ras proteins, which are pivotal in controlling cell proliferation, differentiation, and survival. GRB2 is primarily located in the cytoplasm and forms complexes with activated receptor molecules, such as the epidermal growth factor receptor (EGFR), and guanine nucleotide exchange factors like SOS1. This localization enables GRB2 to act as a critical adaptor that links receptor activation to downstream signaling cascades, thereby influencing various cellular responses. Additionally, GRB2 is essential during embryogenesis, facilitating the differentiation of endodermal cells and the formation of the epiblast, highlighting its importance in developmental biology. GRB2 (E-1) antibody serves as an invaluable tool for researchers studying these complex signaling pathways and their implications in health and disease.

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GRB2 Antibody (E-1) References:

1. Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy.  |  Dharmawardana, PG., et al. 2006. Anticancer Drugs. 17: 13-20. PMID: 16317285
2. Grb2 mediates semaphorin-4D-dependent RhoA inactivation.  |  Sun, T., et al. 2012. J Cell Sci. 125: 3557-67. PMID: 22505611
3. Grb2 regulates the proliferation of hematopoietic stem and progenitors cells.  |  Frelin, C., et al. 2017. Biochim Biophys Acta Mol Cell Res. 1864: 2449-2459. PMID: 28964849
4. Grb2 Induces Cardiorenal Syndrome Type 3: Roles of IL-6, Cardiomyocyte Bioenergetics, and Akt/mTOR Pathway.  |  Wang, J., et al. 2021. Front Cell Dev Biol. 9: 630412. PMID: 33829014
5. Interdomain interactions in Grb2 revealed by the conformational stability and CD28 binding analysis.  |  Ochi, S., et al. 2022. Biophys Chem. 284: 106792. PMID: 35276477
6. The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation.  |  Seiler, C., et al. 2022. Commun Biol. 5: 1029. PMID: 36171279
7. Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators.  |  Bufano, M., et al. 2023. Bioorg Chem. 138: 106607. PMID: 37210829
8. Regulation of microRNA expression by the adaptor protein GRB2.  |  Stainthorp, AK., et al. 2023. Sci Rep. 13: 9784. PMID: 37328606
9. Synthesis and Biochemical Evaluation of Monocarboxylic GRB2 SH2 Domain Inhibitors.  |  Xiao, T., et al. 2023. Methods Mol Biol. 2705: 269-290. PMID: 37668980
10. Porcine deltacoronavirus nucleocapsid protein interacts with the Grb2 through its proline-rich motifs to induce activation of the Raf-MEK-ERK signal pathway and promote virus replication.  |  Li, M., et al. 2024. J Gen Virol. 105: PMID: 39136113

The preferred GRB2 antibody is GRB2 Antibody (C-7): sc-8034.