GRB2 Antibody (1-68): sc-503

GRB2 Antibody (1-68) is a mouse monoclonal IgG2b antibody that detects GRB2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). GRB2 monoclonal antibody (1-68) plays a crucial role in cellular signaling pathways, particularly in the regulation of growth factor-induced activation of Ras proteins, which are pivotal in controlling cell proliferation, differentiation, and survival. GRB2 is primarily located in the cytoplasm and is known for its ability to form complexes with activated receptor molecules, such as the epidermal growth factor receptor (EGFR), and guanine nucleotide exchange factors like SOS1. This localization is significant because GRB2 acts as a critical adaptor that links receptor activation to downstream signaling cascades, thereby influencing various cellular responses. Additionally, GRB2 is essential during embryogenesis, facilitating the differentiation of endodermal cells and the formation of the epiblast, highlighting its importance in developmental biology. GRB2 (1-68) antibody is an invaluable tool for researchers studying these complex signaling pathways and their implications in health and disease.

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GRB2 Antibody (1-68) References:

1. Grb2 signaling in cell motility and cancer.  |  Giubellino, A., et al. 2008. Expert Opin Ther Targets. 12: 1021-33. PMID: 18620523
2. Grb2, a simple adapter with complex roles in lymphocyte development, function, and signaling.  |  Jang, IK., et al. 2009. Immunol Rev. 232: 150-9. PMID: 19909362
3. Allosteric regulation of GRB2 modulates RAS activation.  |  Kazemein Jasemi, NS. and Ahmadian, MR. 2022. Small GTPases. 13: 282-286. PMID: 35703160
4. GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production.  |  Sandouk, A., et al. 2023. Sci Rep. 13: 3505. PMID: 36864087
5. FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.  |  Clark, JF. and Soriano, P. 2023. Biol Open. 12: PMID: 37421147
6. GRB2 serves as a viable target against skin fibrosis in systemic sclerosis by regulating endothelial cell apoptosis.  |  Huang, Y., et al. 2023. J Dermatol Sci. 111: 109-119. PMID: 37661474
7. Progesterone receptor-Grb2 interaction is associated with better outcomes in breast cancer.  |  Wittayavimol, N., et al. 2024. J Steroid Biochem Mol Biol. 237: 106441. PMID: 38070754
8. Ginsenoside Rg3 Restores Mitochondrial Cardiolipin Homeostasis via GRB2 to Prevent Parkinson's Disease.  |  Qi, LF., et al. 2024. Adv Sci (Weinh). 11: e2403058. PMID: 39159293
9. Grb2 Y160F mutant mimics the wild-type monomeric state dynamics and the monomer-dimer equilibrium.  |  Casteluci, G., et al. 2024. Int J Biol Macromol. 279: 134945. PMID: 39182877
10. ROR1 facilitates glioblastoma growth via stabilizing GRB2 to promote c-Fos expression in glioma stem cells.  |  Zhu, H., et al. 2024. Neuro Oncol.. PMID: 39447031

The preferred GRB2 antibody is GRB2 Antibody (C-7): sc-8034.