GR/NR3C1/Glucocorticoid Receptor Antibody (A-4): sc-376425
- GR/NR3C1/Glucocorticoid Receptor Antibody (A-4) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 5-33 at the N-terminus of GR α of mouse origin
- recommended for detection of GR α and GR β of mouse and rat origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-376425 X, 200 µg/0.1 ml)
- See GR/NR3C1/Glucocorticoid Receptor (G-5): sc-393232 for GR/NR3C1/Glucocorticoid Receptor antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP is the preferred secondary detection reagent for GR/NR3C1/Glucocorticoid Receptor Antibody (A-4) for WB applications. This reagent is now offered in a bundle with GR/NR3C1/Glucocorticoid Receptor Antibody (A-4) (see ordering information below).
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GR Antibody (A-4) is a mouse monoclonal IgG2b antibody that detects glucocorticoid receptor (GR) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GR antibody (A-4) plays a crucial role in understanding glucocorticoid receptor function, a key transcription factor involved in mediating physiological effects of glucocorticoids. GR (A-4) antibody helps detect glucocorticoid receptor primarily located in cell cytoplasm, where GR exists in an inactive form bound to heat shock proteins, particularly HSP 90. Upon binding to glucocorticoids, glucocorticoid receptor translocates to the nucleus, regulating expression of target genes vital for processes such as metabolism, immune response, and stress adaptation. GR (A-4) monoclonal antibody enables research on glucocorticoid receptor′s ability to modulate gene expression, which is essential for maintaining homeostasis and responding to environmental changes, making GR a significant focus in endocrinology and immunology research. Anti-GR antibody (A-4) supports studies of glucocorticoid receptor interactions with various co-regulators and transcription factors, including AP-1, highlighting GR′s complex role in gene regulation and potential implications of mutations in diseases such as cancer and metabolic disorders.
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GR/NR3C1/Glucocorticoid Receptor Antibody (A-4) References:
- The glucocorticoid receptor signalling in breast cancer. | Moutsatsou, P. and Papavassiliou, AG. 2008. J Cell Mol Med. 12: 145-63. PMID: 18053085
- Glucocorticoid receptor in human respiratory epithelial cells. | Pujolsa, L., et al. 2009. Neuroimmunomodulation. 16: 290-9. PMID: 19571590
- Targeting inflammation using selective glucocorticoid receptor modulators. | De Bosscher, K., et al. 2010. Curr Opin Pharmacol. 10: 497-504. PMID: 20493772
- Metabolic functions of glucocorticoid receptor in skeletal muscle. | Kuo, T., et al. 2013. Mol Cell Endocrinol. 380: 79-88. PMID: 23523565
- Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis. | Richardson, RV., et al. 2017. J Endocrinol. 232: 437-450. PMID: 28057868
- Natural and synthetic compounds as dissociated agonists of glucocorticoid receptor. | Zhang, T., et al. 2020. Pharmacol Res. 156: 104802. PMID: 32278042
- Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy. | Srivastava, SP., et al. 2021. Nat Commun. 12: 2368. PMID: 33888696
- The glucocorticoid receptor modulator relacorilant reverses the immunosuppressive effects of cortisol. | Greenstein, AE. and Hunt, HJ. 2023. Int Immunopharmacol. 120: 110312. PMID: 37230031
- Activation of the glucocorticoid-receptor complex. | Schmidt, TJ., et al. 1982. J Cell Biochem. 20: 15-27. PMID: 6761347
- Structure and function of the glucocorticoid receptor. | Wright, AP., et al. 1993. J Steroid Biochem Mol Biol. 47: 11-9. PMID: 8274424
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GR/NR3C1/Glucocorticoid Receptor Antibody (A-4) | sc-376425 | 200 µg/ml | $322.00 | |||
GR/NR3C1/Glucocorticoid Receptor Antibody (A-4): m-IgG2b BP-HRP Bundle | sc-548597 | 200 µg Ab; 10 µg BP | $361.00 | |||
GR/NR3C1/Glucocorticoid Receptor (A-4) Neutralizing Peptide | sc-376425 P | 100 µg/0.5 ml | $69.00 | |||
GR/NR3C1/Glucocorticoid Receptor Antibody (A-4) X | sc-376425 X | 200 µg/0.1 ml | $322.00 |