Glutathione Peroxidase 1/2/GPX1/2 Antibody (E-7): sc-74498

GPx-1/2 Antibody (E-7) is a mouse monoclonal IgG2b antibody that detects glutathione peroxidase 1 and 2 (GPx-1/2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPx-1/2 plays a crucial role in cellular antioxidant defense by catalyzing the reduction of harmful lipid hydroperoxides and hydrogen peroxide, thereby protecting cells from oxidative damage. Anti-GPx-1/2 antibody (E-7) is particularly useful for studying tissues highly susceptible to oxidative stress, such as the vascular wall and neural cells, where GPx-1 is predominantly expressed. The presence of selenocysteine at the active site of GPx-1/2 is vital for enzymatic activity, as selenocysteine enhances the ability to neutralize reactive oxygen species. Additionally, GPx-2, the major isoform in the lungs, is regulated by the transcription factor Nrf2, which responds to oxidative stress, highlighting GPx-1/2′s significance in maintaining cellular homeostasis. GPx-1/2 (E-7) antibody serves as an essential tool for researchers studying oxidative stress responses and the protective mechanisms of these critical enzymes in various biological contexts.

The preferred Glutathione Peroxidase 1/2/GPX1/2 antibody is Glutathione Peroxidase 1/2/GPX1/2 Antibody (B-6): sc-133160.