GPR43 Antibody (3B3): sc-293202

GPR43 Antibody (3B3) is a mouse monoclonal IgG2a kappa light chain antibody that detects GPR43 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GPR43 antibody (3B3) is available as the non-conjugated format. GPR43, also known as FFAR2, is a member of the G protein-coupled receptor family, which plays a crucial role in mediating the effects of short-chain fatty acids (SCFAs) such as acetate and propionate. These SCFAs are produced by gut bacteria and released into the bloodstream, where they influence various cellular processes, including the activation of leukocytes. The interaction of GPR43 with SCFAs is particularly important for the recruitment of immune cells, especially polymorphonuclear cells, to sites of infection, thereby contributing to the body′s immune response. The ability of GPR43 to modulate immune cell activity highlights its potential as a therapeutic target in inflammatory diseases and metabolic disorders. GPR43 monoclonal antibody (3B3) is an essential tool for researchers investigating the role of this receptor in health and disease.

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GPR43 Antibody (3B3) References:

1. LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3.  |  Senga, T., et al. 2003. Blood. 101: 1185-7. PMID: 12393494
2. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.  |  Brown, AJ., et al. 2003. J Biol Chem. 278: 11312-9. PMID: 12496283
3. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.  |  Briscoe, CP., et al. 2003. J Biol Chem. 278: 11303-11. PMID: 12496284
4. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.  |  Nilsson, NE., et al. 2003. Biochem Biophys Res Commun. 303: 1047-52. PMID: 12684041
5. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.  |  Le Poul, E., et al. 2003. J Biol Chem. 278: 25481-9. PMID: 12711604
6. Continued discovery of ligands for G protein-coupled receptors.  |  Lee, DK., et al. 2003. Life Sci. 74: 293-7. PMID: 14607257
7. Sphk2-/- mice are protected from obesity and insulin resistance.  |  Ravichandran, S., et al. 2019. Biochim Biophys Acta Mol Basis Dis. 1865: 570-576. PMID: 30593892
8. SphK2/S1P Promotes Metastasis of Triple-Negative Breast Cancer Through the PAK1/LIMK1/Cofilin1 Signaling Pathway.  |  Shi, W., et al. 2021. Front Mol Biosci. 8: 598218. PMID: 33968977
9. miR-153-3p Attenuates the Development of Gastric Cancer by Suppressing SphK2.  |  Jia, Z., et al. 2022. Biochem Genet. 60: 1748-1761. PMID: 35088224
10. Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation.  |  Dai, L., et al. 2022. Open Med (Wars). 17: 229-238. PMID: 35178477
11. Nuclear SPHK2/S1P induces oxidative stress and NLRP3 inflammasome activation via promoting p53 acetylation in lipopolysaccharide-induced acute lung injury.  |  Gong, L., et al. 2023. Cell Death Discov. 9: 12. PMID: 36653338
12. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.  |  Sawzdargo, M., et al. 1997. Biochem Biophys Res Commun. 239: 543-7. PMID: 9344866

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GPR43 Antibody (3B3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-GPR43 Antibody (3B3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GPR43 Antibody (3B3) Specifications

Alternate Product Name: GPR43

Product Clone Name: 3B3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 231-330

Epitope Target: GPR43

Epitope Species: human

Product Reactivity/Detection: GPR43

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for GPR43 Antibody (3B3): N/A