GPR17 Antibody (A-10): sc-514723

GPR17 Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects GPR17 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPR17 Antibody (A-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. G protein-coupled receptor 17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family. This receptor is predominantly expressed in the brain, where GPR17 plays a critical role in responding to extracellular signals, particularly during brain injury. Upon injury, the levels of nucleotides and cysteinyl leukotrienes increase significantly, leading to GPR17 upregulation in certain neurons within the affected area. This upregulation is crucial as GPR17 mediates neuronal death, facilitates the remodeling of brain circuitries by microglia, and initiates the remyelination process in damaged neurons. Notably, GPR17 undergoes alternative splicing, resulting in two named isoforms, which may have distinct functional roles in cellular signaling and response to injury.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GPR17 Antibody (A-10) References:

1. Discovery and mapping of ten novel G protein-coupled receptor genes.  |  Lee, DK., et al. 2001. Gene. 275: 83-91. PMID: 11574155
2. Molecular modeling as a tool to investigate molecular recognition in P2Y receptors.  |  Moro, S. and Jacobson, KA. 2002. Curr Pharm Des. 8: 2401-13. PMID: 12369952
3. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.  |  von Kügelgen, I. 2006. Pharmacol Ther. 110: 415-32. PMID: 16257449
4. Mitochondrial calcium transport is regulated by P2Y1- and P2Y2-like mitochondrial receptors.  |  Belous, AE., et al. 2006. J Cell Biochem. 99: 1165-74. PMID: 16795051
5. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.  |  Ciana, P., et al. 2006. EMBO J. 25: 4615-27. PMID: 16990797
6. GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.  |  Parravicini, C., et al. 2008. BMC Bioinformatics. 9: 263. PMID: 18533035
7. Development of an immobilized GPR17 receptor stationary phase for binding determination using frontal affinity chromatography coupled to mass spectrometry.  |  Temporini, C., et al. 2009. Anal Biochem. 384: 123-9. PMID: 18835238
8. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.  |  Lecca, D., et al. 2008. PLoS One. 3: e3579. PMID: 18974869
9. GPR17 receptor modulators and their therapeutic implications: review of recent patents.  |  Marucci, G., et al. 2019. Expert Opin Ther Pat. 29: 85-95. PMID: 30640576
10. Regulation and signaling of the GPR17 receptor in oligodendroglial cells.  |  Lecca, D., et al. 2020. Glia. 68: 1957-1967. PMID: 32086854
11. Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia.  |  Wang, J., et al. 2020. Neuron. 108: 876-886.e4. PMID: 33108748
12. Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice.  |  Liang, Y., et al. 2023. J Neuroinflammation. 20: 271. PMID: 37990234

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GPR17 Antibody (A-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-GPR17 Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GPR17 Antibody (A-10) Specifications

Alternate Product Name: GPR17

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 278-367

Epitope Target: GPR17

Epitope Species: human

Product Reactivity/Detection: GPR17

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for GPR17 Antibody (A-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin