Date published: 2026-5-17

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GPR17 Activators

The chemical class GPR17 Activators encompasses compounds that indirectly influence GPR17, a G-protein-coupled receptor integral to oligodendrocyte differentiation and myelination. These compounds interact with signaling pathways, particularly those involving purinergic and leukotriene signaling, which are key to GPR17's functional modulation. Nucleosides like Uridine and Adenosine, known for their roles in purinergic signaling, are natural ligands for purinergic receptors. Their interaction with these receptors can modulate signaling pathways that GPR17 is responsive to, highlighting the receptor's sensitivity to changes in purinergic signaling dynamics. Cysteinyl leukotrienes (LTC4, LTD4, LTE4), acting as GPR17 ligands, and their antagonists, including Montelukast, Pranlukast, and Zafirlukast, further underscore the interplay between GPR17 and inflammatory signaling pathways. These leukotriene receptor antagonists influence leukotriene pathways, thereby indirectly affecting GPR17's activity.Additionally, compounds like BIBU 104, MDL29,951, MRS2179, Suramin, Reactive Blue 2, and PPADS, primarily antagonists of various purinergic receptors, play a significant role in modulating purinergic signaling pathways. This modulation can indirectly affect GPR17 activity. For instance, Suramin and Reactive Blue 2, as P2 receptor antagonists, alter the signaling landscape in which GPR17 operates, potentially impacting its functional state.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PF9 tetrasodium salt

851265-78-6sc-362783
1 mg
$235.00
(0)

PF9 tetrasodium salt functions as a GPR17 modulator, exhibiting a unique affinity for the receptor's orthosteric binding site. This interaction triggers specific downstream signaling pathways, influencing cellular responses. Its ionic nature enhances solubility and facilitates rapid diffusion across membranes, promoting efficient receptor engagement. The compound's distinct charge distribution and steric configuration contribute to its selective binding kinetics, allowing for precise modulation of GPR17 activity.

Uridine-5′-diphosphoglucose, disodium salt

117756-22-6sc-296687
sc-296687A
sc-296687B
sc-296687C
sc-296687D
sc-296687E
100 mg
1 g
10 g
50 g
100 g
1 kg
$99.00
$458.00
$2611.00
$13015.00
$16657.00
$41106.00
1
(1)

Uridine-5'-diphosphoglucose, disodium salt acts as a GPR17 modulator, characterized by its ability to engage in specific hydrogen bonding interactions with receptor sites. This compound influences intracellular signaling cascades, impacting various metabolic pathways. Its dual phosphate groups enhance electrostatic interactions, promoting stability in aqueous environments. The compound's unique stereochemistry allows for tailored binding dynamics, facilitating nuanced regulatory effects on GPR17 activity.

Uridine

58-96-8sc-296685
sc-296685A
1 g
25 g
$61.00
$100.00
1
(1)

A nucleoside that can bind to GPR17, potentially modulating its activity by influencing purinergic signaling pathways.

ONO 1078

103177-37-3sc-204148
50 mg
$66.00
(0)

Another leukotriene receptor antagonist, it can indirectly influence GPR17 activity through the modulation of leukotriene pathways.

Zafirlukast

107753-78-6sc-204942
sc-204942A
10 mg
100 mg
$37.00
$174.00
1
(1)

A leukotriene receptor antagonist, potentially affecting GPR17 by altering leukotriene signaling pathways.

Adenosine

58-61-7sc-291838
sc-291838A
sc-291838B
sc-291838C
sc-291838D
sc-291838E
sc-291838F
1 g
5 g
100 g
250 g
1 kg
5 kg
10 kg
$34.00
$48.00
$300.00
$572.00
$1040.00
$2601.00
$4682.00
1
(0)

A purine nucleoside that can influence purinergic signaling pathways, potentially modulating GPR17 activity.

Suramin sodium

129-46-4sc-507209
sc-507209F
sc-507209A
sc-507209B
sc-507209C
sc-507209D
sc-507209E
50 mg
100 mg
250 mg
1 g
10 g
25 g
50 g
$152.00
$214.00
$728.00
$2601.00
$10965.00
$21838.00
$41096.00
5
(1)

A P2 receptor antagonist, can influence purinergic signaling, indirectly affecting GPR17 activity.