GPR14 Antibody (D-1): sc-515569
- GPR14 Antibody (D-1) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 27-45 near the N-terminus of GPR14 of human origin
- recommended for detection of GPR14 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GPR14 Antibody (D-1). This work is in progress.
GPR14 Antibody (D-1) is a mouse monoclonal IgM antibody that detects GPR14 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPR14, also known as the sensory epithelium neuropeptide-like receptor, is a G-protein-coupled receptor that was initially identified as an orphan receptor, meaning it binds to an unidentified natural ligand. Subsequent research has revealed that urotensin II, a cyclic neuropeptide, binds to GPR14 with high affinity, leading to an increase in intracellular calcium levels in cells expressing this receptor. The localization of GPR14 in heart tissues is particularly significant, as GPR14 suggests a role in the contraction of vascular smooth muscles in response to urotensin II, which is crucial for regulating blood pressure and cardiovascular function. Additionally, GPR14 is present in the pancreas and, to a lesser extent, in brain tissues, indicating GPR14′s potential involvement in various physiological processes across different organ systems. Anti-GPR14 antibody (D-1) is an essential tool for researchers investigating the physiological and pathological roles of this receptor in various biological contexts.
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GPR14 Antibody (D-1) References:
- Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. | Ames, RS., et al. 1999. Nature. 401: 282-6. PMID: 10499587
- Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14). | Mori, M., et al. 1999. Biochem Biophys Res Commun. 265: 123-9. PMID: 10548501
- Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization. | Protopopov, A., et al. 2000. Cytogenet Cell Genet. 88: 312-3. PMID: 10828617
- Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954). | Croston, GE., et al. 2002. J Med Chem. 45: 4950-3. PMID: 12408704
- Urotensin-II, a neuropeptide ligand for GPR14, induces c-fos in the rat brain. | Gartlon, JE., et al. 2004. Eur J Pharmacol. 493: 95-8. PMID: 15189768
- Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. | Bousette, N., et al. 2004. Atherosclerosis. 176: 117-23. PMID: 15306183
- Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension. | Liu, D., et al. 2010. Int J Mol Med. 25: 845-51. PMID: 20428787
- UII/GPR14 is involved in NF-κB-mediated colonic inflammation in vivo and in vitro. | Yang, Y., et al. 2016. Oncol Rep. 36: 2800-2806. PMID: 27600191
- Microinjection of urotensin II into the rostral ventrolateral medulla increases sympathetic vasomotor tone via the GPR14/ERK pathway in rats. | Cao, YK., et al. 2020. Hypertens Res. 43: 765-771. PMID: 32385485
- Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice. | Yang, H., et al. 2023. J Invest Dermatol. 143: 2546-2550.e6. PMID: 37247724
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GPR14 Antibody (D-1) | sc-515569 | 200 µg/ml | $322.00 | |||
GPR14 (D-1) Neutralizing Peptide | sc-515569 P | 100 µg/0.5 ml | $69.00 |