Date published: 2025-12-13

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GPR14 Activators

GPR14 activators, as identified in this list, are primarily compounds that can potentially influence GPR14 activity either directly, as in the case of its natural ligand Urotensin-II, or indirectly through modulation of related signaling pathways or systemic physiological effects. These compounds do not necessarily bind directly to GPR14 but may affect the receptor's activity in the context of vascular physiology and regulation.Urotensin-II and Urotensin-II related peptide (URP) are the most direct activators of GPR14, with Urotensin-II being the natural agonist for this receptor. Palosuran, initially developed as an antagonist, may exhibit partial agonist activity under certain conditions, representing a more complex interaction with GPR14. Other compounds like Isoproterenol, Acetylcholine, Angiotensin II, Endothelin-1, Norepinephrine, Phenylephrine, Vasopressin, Epinephrine, and Serotonin influence vascular tone and signaling pathways. While these do not target GPR14 directly, their roles in cardiovascular regulation could indirectly affect GPR14 activity, especially given the receptor's involvement in vasoconstriction and cardiovascular functions.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(±)-AC 7954 hydrochloride

477313-09-0sc-203491
1 mg
$200.00
(0)

(±)-AC 7954 hydrochloride acts as a GPR14 modulator, characterized by its ability to selectively engage with the receptor's allosteric sites. This interaction induces conformational changes that facilitate unique signaling cascades, impacting cellular communication and homeostasis. The compound's distinct stereochemistry contributes to its binding dynamics, promoting a nuanced response in receptor activation. Its kinetic behavior indicates a balanced rate of association and dissociation, allowing for fine-tuned regulatory effects on GPR14-mediated pathways.

Isoproterenol Hydrochloride

51-30-9sc-202188
sc-202188A
100 mg
500 mg
$27.00
$37.00
5
(0)

Isoproterenol, a non-selective beta-adrenergic agonist, may indirectly influence GPR14 activity through cross-talk with adrenergic receptors.

Angiotensin II, Human

4474-91-3sc-363643
sc-363643A
sc-363643B
sc-363643C
1 mg
5 mg
25 mg
100 mg
$50.00
$75.00
$260.00
$505.00
3
(1)

Angiotensin II, while primarily acting on its own receptors, could potentially influence GPR14 activity indirectly through cardiovascular system effects.

(±)-Norepinephrine (+)-bitartrate salt

3414-63-9sc-255396
1 g
$112.00
(1)

Norepinephrine, a key neurotransmitter, could potentially influence GPR14 indirectly via its effects on vascular tone and signaling pathways.

L-phenylephrine

59-42-7sc-295315
sc-295315A
5 g
25 g
$177.00
$482.00
2
(0)

Phenylephrine, an alpha-1 adrenergic receptor agonist, may have indirect effects on GPR14 through vascular signaling pathways.

Vasopressin

11000-17-2sc-356188
sc-356188A
5 mg
25 mg
$255.00
$1020.00
1
(0)

Vasopressin, another potent vasoactive peptide, could indirectly affect GPR14 signaling in the context of blood pressure regulation.

(−)-Epinephrine

51-43-4sc-205674
sc-205674A
sc-205674B
sc-205674C
sc-205674D
1 g
5 g
10 g
100 g
1 kg
$40.00
$102.00
$197.00
$1739.00
$16325.00
(1)

Epinephrine, a central adrenergic agonist, might indirectly modulate GPR14 activity through its systemic vasoactive effects.

Serotonin hydrochloride

153-98-0sc-201146
sc-201146A
100 mg
1 g
$116.00
$183.00
15
(1)

Serotonin, a neurotransmitter with diverse physiological roles, could potentially influence GPR14 indirectly via its vascular effects.