GPI Antibody (E-4): sc-398382

GPI Antibody (E-4) is a mouse monoclonal IgG2b antibody that detects glucose-6-phosphate isomerase (GPI) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPI is a crucial enzyme that plays a significant role in the glycolytic and gluconeogenic pathways, facilitating the interconversion of glucose-6-phosphate and fructose-6-phosphate. GPI (E-4) antibody supports research into cellular energy homeostasis and metabolic balance, particularly in tissues with high energy demands. GPI monoclonal antibody (E-4) enables studies of GPI′s function as a neurotrophic factor, supporting the survival and growth of spinal and sensory neurons, which underscores its importance in both metabolic processes and neurobiology. Mutations or deficiencies in GPI can lead to severe health issues, including hereditary nonspherocytic hemolytic anemia, hydrops fetalis, and neurological impairments, highlighting GPI′s critical role in human health. Anti-GPI antibody (E-4) serves as an essential tool for researchers studying these pathways and their implications in various diseases.

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GPI Antibody (E-4) References:

1. The exploration of joint-specific immunoreactions on immunoglobulins G of anti-glucose-6-phosphate isomerase antibody-positive patients with rheumatoid arthritis.  |  Matsumoto, I., et al. 2005. Int J Mol Med. 16: 793-800. PMID: 16211246
2. A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies.  |  Matsumoto, I., et al. 2005. Arthritis Res Ther. 7: R1183-8. PMID: 16277670
3. Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours.  |  Dobashi, Y., et al. 2006. J Pathol. 208: 44-53. PMID: 16294294
4. Characterisation of Th1/Th2 type, glucose-6-phosphate isomerase reactive T cells in the generation of rheumatoid arthritis.  |  Kori, Y., et al. 2006. Ann Rheum Dis. 65: 968-9. PMID: 16769785
5. Differential expression and pathological significance of autocrine motility factor/glucose-6-phosphate isomerase expression in human lung carcinomas.  |  Dobashi, Y., et al. 2006. J Pathol. 210: 431-40. PMID: 17029220
6. Crystal structure of glucose-6-phosphate isomerase from Thermus thermophilus HB8 showing a snapshot of active dimeric state.  |  Yamamoto, H., et al. 2008. J Mol Biol. 382: 747-62. PMID: 18675274
7. Amoxicillin-induced hemolytic anemia in a child with glucose 6-phosphate isomerase deficiency.  |  Rossi, F., et al. 2010. Ann Pharmacother. 44: 1327-9. PMID: 20516363
8. Isolation and characterization of human glucose-6-phosphate isomerase isoforms containing two different size subunits.  |  Sun, AQ., et al. 1990. Arch Biochem Biophys. 283: 120-9. PMID: 2241164
9. DNA sequence abnormalities in human glucose 6-phosphate isomerase deficiency.  |  Walker, JI., et al. 1993. Hum Mol Genet. 2: 327-9. PMID: 8499925
10. Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency.  |  Kugler, W., et al. 1998. Hum Genet. 103: 450-4. PMID: 9856489

The preferred GPI antibody is GPI Antibody (H-10): sc-365066.