gp91phox/CYBB/NOX2 Antibody (NL7): sc-130548

gp91-phox Antibody (NL7) is a mouse monoclonal IgG1 antibody that detects gp91-phox in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). gp91-phox, a crucial component of the NADPH oxidase complex, plays a vital role in generating reactive oxygen species, which are essential for various cellular processes, including host defense and signaling pathways. gp91-phox is primarily located in the plasma membrane of phagocytes, such as neutrophils and eosinophils, where gp91-phox forms a functional unit with p22-phox and other cytosolic proteins during NADPH oxidase activation. gp91-phox localization at the membrane allows for rapid superoxide generation in response to stimuli, facilitating immune response against pathogens. gp91-phox is involved in cellular signaling mechanisms that respond to hypoxic conditions, highlighting gp91-phox importance in both oxidative stress responses and cellular communication. gp91-phox distinct expression patterns, particularly in immune cells and upregulation in vascular smooth muscle cells under certain conditions, suggest diverse roles beyond traditional function in phagocytes, potentially influencing inflammation and vascular biology. anti-gp91-phox antibody (NL7) serves as an invaluable tool for researchers studying oxidative stress, immune responses, and related signaling pathways.

The preferred gp91phox/CYBB/NOX2 antibody is gp91phox/CYBB/NOX2 Antibody (54.1): sc-130543.