gp91phox/CYBB/NOX2 Antibody (G-1): sc-74514

gp91-phox Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects gp91-phox in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). gp91-phox (G-1) antibody is offered in a non-conjugated form, allowing for versatile experimental setups. gp91-phox, also known as CYBB, plays a crucial role in the function of the NADPH oxidase complex, which is essential for generating reactive oxygen species in various immune and vascular cells. gp91-phox is primarily located in the membrane of phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells, where gp91-phox forms part of a larger enzyme complex that includes p22-phox, p47-phox, and p67-phox. gp91-phox localization enables rapid response to oxidative stress and hypoxic conditions, facilitating cellular signaling pathways critical for immune responses and vascular health. gp91-phox subunit acts as a surface oxygen sensor, initiating signaling cascades that help cells adapt to low oxygen levels. gp91-phox and its homolog Mox1, primarily found in the colon and upregulated in vascular smooth muscle cells in response to platelet-derived growth factor stimulation, share structural similarities yet may have specialized roles in regulating superoxide production in different cellular contexts.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-gp91phox/CYBB/NOX2 Antibody (G-1) has 41 citations in a variety of scientific publications.

Primary antibodies like Anti-gp91phox/CYBB/NOX2 Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

gp91phox/CYBB/NOX2 Antibody (G-1) Specifications

Alternate Product Name: CYBB

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 231-290

Epitope Target: gp91-phox

Epitope Species: human

Product Reactivity/Detection: gp91-phox

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 41 citations in various scientific publications

Available Conjugates/Forms for gp91phox/CYBB/NOX2 Antibody (G-1): N/A

The preferred gp91phox/CYBB/NOX2 antibody is gp91phox/CYBB/NOX2 Antibody (54.1): sc-130543.