CD130/gp130 Antibody (E-8): sc-376280

gp130 Antibody (E-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects gp130 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-gp130 antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. gp130 plays a crucial role in the signaling pathways of several cytokines, including interleukin-6 (IL-6), which is vital for immune response regulation and inflammation. Upon IL-6 binding to its receptor, gp130 forms a dimer that is essential for the activation of downstream signaling cascades, such as the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. This pathway is important for various cellular processes, including cell survival, proliferation, and differentiation, making gp130 a key player in both normal physiological functions and pathological conditions, such as autoimmune diseases and cancers. gp130′s ability to interact with multiple cytokine receptors further underscores its significance in mediating complex signaling networks, highlighting the value of gp130 (E-8) antibody in research to better understand these critical biological processes.

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CD130/gp130 Antibody (E-8) References:

1. Conditional gp130 deficient mouse mutants.  |  Fasnacht, N. and Müller, W. 2008. Semin Cell Dev Biol. 19: 379-84. PMID: 18687405
2. gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis.  |  Sodenkamp, J., et al. 2011. Eur J Cell Biol. 90: 505-14. PMID: 21144615
3. Molecular cloning and expression of an IL-6 signal transducer, gp130.  |  Hibi, M., et al. 1990. Cell. 63: 1149-57. PMID: 2261637
4. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.  |  Taga, T., et al. 1989. Cell. 58: 573-81. PMID: 2788034
5. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.  |  Yamasaki, K., et al. 1988. Science. 241: 825-8. PMID: 3136546
6. GP130 Cytokines in Breast Cancer and Bone.  |  Omokehinde, T. and Johnson, RW. 2020. Cancers (Basel). 12: PMID: 32023849
7. Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.  |  Namiki, T., et al. 2023. Sci Rep. 13: 854. PMID: 36646738
8. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.  |  Hilton, DJ., et al. 1994. EMBO J. 13: 4765-75. PMID: 7957045
9. The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.  |  Müllberg, J., et al. 1994. J Immunol. 152: 4958-68. PMID: 8176214
10. Cytokine signal transduction.  |  Kishimoto, T., et al. 1994. Cell. 76: 253-62. PMID: 8293462
11. LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.  |  Davis, S., et al. 1993. Science. 260: 1805-8. PMID: 8390097
12. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.  |  Murakami, M., et al. 1991. Proc Natl Acad Sci U S A. 88: 11349-53. PMID: 1662392

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD130/gp130 Antibody (E-8) has 31 citations in a variety of scientific publications.

Primary antibodies like Anti-CD130/gp130 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD130/gp130 Antibody (E-8) Specifications

Alternate Product Name: IL6ST

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 365-619

Epitope Target: gp130

Epitope Species: human

Product Reactivity/Detection: gp130

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for CD130/gp130 Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin