GP-39 Antibody (D-6): sc-376941

GP-39 Antibody (D-6) is a mouse monoclonal IgG2b antibody that detects human cartilage glycoprotein 39 (GP-39) in mouse samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GP-39, also known as YKL-40, is a glycoprotein secreted primarily by articular chondrocytes, synoviocytes, and macrophages, playing a crucial role in inflammatory response and tissue remodeling. Elevated levels of GP-39 in serum and synovial fluid are associated with inflammatory diseases, particularly rheumatoid arthritis, where GP-39 levels correlate with joint destruction extent. GP-39 is predominantly expressed in articular chondrocytes and synovial cells, with additional expression in liver, while being absent in muscle tissues, lung, pancreas, mononuclear cells, and fibroblasts. As a candidate autoantigen in rheumatoid arthritis, GP-39 demonstrates significance in immune response and cellular adaptation to environmental changes. GP-39 (D-6) antibody provides researchers with a valuable tool for investigating GP-39′s role in various pathological conditions, enabling deeper understanding of GP-39 function and potential as a therapeutic target.

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GP-39 Antibody (D-6) References:

1. GP-83 and GP-39, two glycoproteins secreted by human epididymis are conjugated to spermatozoa during maturation.  |  Liu, HW., et al. 2000. Mol Hum Reprod. 6: 422-8. PMID: 10775645
2. Human cartilage gp-39+,CD16+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis.  |  Baeten, D., et al. 2000. Arthritis Rheum. 43: 1233-43. PMID: 10857782
3. Cellular immune response to human cartilage glycoprotein-39 (HC gp-39)-derived peptides in rheumatoid arthritis and other inflammatory conditions.  |  Vos, K., et al. 2000. Rheumatology (Oxford). 39: 1326-31. PMID: 11136874
4. Classification of mutations in the human CD40 ligand, gp39, that are associated with X-linked hyper IgM syndrome.  |  Bajorath, J., et al. 1996. Protein Sci. 5: 531-4. PMID: 16509032
5. HC-gp39 contributes to chondrocyte differentiation by inducing SOX9 and type II collagen expressions.  |  Jacques, C., et al. 2007. Osteoarthritis Cartilage. 15: 138-46. PMID: 16949314
6. Evolutionary insights into sequence modifications governing chitin recognition and chitinase inactivity in YKL-40 (HC-gp39, CHI3L1).  |  Suzuki, K., et al. 2024. J Biol Chem. 300: 107365. PMID: 38750795
7. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.  |  Foy, TM., et al. 1993. J Exp Med. 178: 1567-75. PMID: 7693850
8. The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.  |  Roy, M., et al. 1993. J Immunol. 151: 2497-510. PMID: 8103067
9. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.  |  Hakala, BE., et al. 1993. J Biol Chem. 268: 25803-10. PMID: 8245017
10. The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells.  |  Griggs, ND., et al. 1996. J Exp Med. 183: 801-10. PMID: 8642284

The preferred GP-39 antibody is GP-39 Antibody (E-11): sc-376910.