GP-39 Antibody (A-10): sc-393590

GP-39 Antibody (A-10) is a mouse monoclonal IgG1 antibody that detects human cartilage glycoprotein 39 (GP-39) by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GP-39, also known as YKL-40, is a glycoprotein secreted primarily by articular chondrocytes, synoviocytes, and macrophages, playing a crucial role in inflammatory response and tissue remodeling. Elevated levels of GP-39 in serum and synovial fluid are associated with inflammatory diseases, particularly rheumatoid arthritis, where GP-39 levels correlate with the extent of joint destruction. GP-39 is predominantly expressed in articular chondrocytes and synovial cells, with additional expression in the liver, while remaining undetectable in muscle tissues, lung, pancreas, mononuclear cells, and fibroblasts. Notably, GP-39 is recognized as a candidate autoantigen in rheumatoid arthritis, highlighting GP-39′s significance in immune response and cellular adaptation to environmental changes. GP-39 (A-10) antibody serves as an essential tool for researchers investigating GP-39′s role in various pathological conditions, providing insights into GP-39′s function and potential as a biomarker for disease progression.

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GP-39 Antibody (A-10) References:

1. Mechanisms underlying the development of T-cell tolerance following interruption of signalling at the CD28/B7 and CD40/gp39 interface.  |  Rastellini, C., et al. 1999. Transplant Proc. 31: 845. PMID: 10083368
2. Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization.  |  Connor, JR., et al. 2000. Osteoarthritis Cartilage. 8: 87-95. PMID: 10772238
3. Functions of CD40 and Its Ligand, gp39 (CD40L).  |  Laman, JD., et al. 2017. Crit Rev Immunol. 37: 371-420. PMID: 29773027
4. Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.  |  Durie, FH., et al. 1994. J Clin Invest. 94: 1333-8. PMID: 7521888
5. The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency.  |  Ochs, HD., et al. 1994. Semin Immunol. 6: 337-41. PMID: 7532462
6. In vivo gp39-CD40 interactions occur in the non-follicular compartments of the spleen and are essential for thymus dependent antibody responses and germinal center formation.  |  van den Eertwegh, AJ., et al. 1994. Adv Exp Med Biol. 355: 75-80. PMID: 7535976
7. Signaling via major histocompatibility complex class II molecules and antigen receptors enhances the B cell response to gp39/CD40 ligand.  |  Bishop, GA., et al. 1995. Eur J Immunol. 25: 1230-8. PMID: 7539751
8. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.  |  Kiener, PA., et al. 1995. J Immunol. 155: 4917-25. PMID: 7594496
9. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.  |  Aruffo, A., et al. 1993. Cell. 72: 291-300. PMID: 7678782
10. The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation.  |  Schubert, LA., et al. 1995. J Biol Chem. 270: 29624-7. PMID: 8530342

The preferred GP-39 antibody is GP-39 Antibody (E-11): sc-376910.