GnRH II Antibody (B-9): sc-55459

GnRH II Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects GnRH II in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GnRH II, a decapeptide, plays a crucial role in the regulation of reproductive functions and is primarily involved in the hypothalamic-pituitary-gonadal axis, influencing the release of luteinizing hormone and follicle-stimulating hormone from the anterior pituitary. Notably, GnRH II is expressed not only in the hypothalamus but also in various peripheral tissues, including the kidney, bone marrow, and prostate, indicating potential involvement in multiple physiological processes beyond reproduction. GnRH II presence in the acrosomal region of human sperm suggests a role in fertilization, while expression in cancer cells raises questions about involvement in tumor biology. GnRH II is encoded by a gene located on human chromosome 20p13, and unique expression pattern, particularly outside the brain, highlights the importance of understanding diverse functions and interactions within different cellular contexts. Anti-GnRH II antibody (B-9) is an essential tool for researchers investigating the multifaceted roles of this peptide in both reproductive health and disease.

The preferred GnRH II antibody is GnRH II Antibody (D-9): sc-25344.