GnRH II Antibody (D-9): sc-25344
- GnRH II Antibody (D-9) is a mouse monoclonal IgG1 κ GnRH II antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-120 of GnRH II of human origin
- GnRH II Antibody (D-9) is recommended for detection of GnRH II of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-GnRH II Antibody (D-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GnRH II Antibody (D-9) for WB and IHC(P) applications. These reagents are now offered in bundles with GnRH II Antibody (D-9) (see ordering information below).
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GnRH II Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects GnRH II protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-GnRH II antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GnRH II plays a crucial role in reproductive functions, particularly in the midbrain, where GnRH II is involved in modulating gonadotropin release. This decapeptide is essential for the hypothalamic-pituitary-gonadal axis and exhibits significant expression in tissues outside the brain, such as kidney, bone marrow, and prostate, indicating potential involvement in various physiological processes beyond reproduction. GnRH II′s unique expression pattern suggests interactions with specific proteins in these tissues, influencing cellular signaling pathways and contributing to functions such as cell proliferation and differentiation. Through binding to specific G protein-coupled receptors in the pituitary, GnRH II regulates luteinizing hormone and follicle-stimulating hormone synthesis and secretion, maintaining a vital role in reproductive health and development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GnRH II Antibody (D-9) References:
- Gonadotropin-releasing hormone agonist has the ability to induce increased matrix metalloproteinase (MMP)-2 and membrane type 1-MMP expression in corpora lutea, and structural luteolysis in rats. | Goto, T., et al. 1999. J Endocrinol. 161: 393-402. PMID: 10333542
- Immunoidentification of gonadotropin releasing hormone receptor in human sperm, pituitary and cancer cells. | Lee, CY., et al. 2000. Am J Reprod Immunol. 44: 170-7. PMID: 11028904
- Proliferation of TSU-Pr1, a human prostatic carcinoma cell line is stimulated by gonadotropin-releasing hormone. | Enomoto, M., et al. 2004. Life Sci. 74: 3141-52. PMID: 15081579
- Pro7.33(303) of the human GnRH receptor regulates selective binding of mammalian GnRH. | Fromme, BJ., et al. 2004. Mol Cell Endocrinol. 219: 47-59. PMID: 15149726
- Gonadotropin-releasing hormone agonist inhibits estrone sulfatase expression of cystic endometriosis in the ovary. | Maitoko, K. and Sasaki, H. 2004. Fertil Steril. 82: 322-6. PMID: 15302278
- Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor. | Maudsley, S., et al. 2004. Cancer Res. 64: 7533-44. PMID: 15492280
- Characterization of cDNA for precursor of human luteinizing hormone releasing hormone. | Seeburg, PH. and Adelman, JP. Nature. 311: 666-8. PMID: 6090951
- Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. | Grosse, R., et al. 1997. Mol Endocrinol. 11: 1305-18. PMID: 9259321
- Second gene for gonadotropin-releasing hormone in humans. | White, RB., et al. 1998. Proc Natl Acad Sci U S A. 95: 305-9. PMID: 9419371
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GnRH II Antibody (D-9) | sc-25344 | 200 µg/ml | $316.00 | |||
GnRH II Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-526654 | 200 µg Ab; 10 µg BP | $354.00 | |||
GnRH II Antibody (D-9): m-IgG1 BP-HRP Bundle | sc-532027 | 200 µg Ab; 20 µg BP | $354.00 | |||
GnRH II Antibody (D-9) AC | sc-25344 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GnRH II Antibody (D-9) HRP | sc-25344 HRP | 200 µg/ml | $316.00 | |||
GnRH II Antibody (D-9) FITC | sc-25344 FITC | 200 µg/ml | $330.00 | |||
GnRH II Antibody (D-9) PE | sc-25344 PE | 200 µg/ml | $343.00 | |||
GnRH II Antibody (D-9) Alexa Fluor® 488 | sc-25344 AF488 | 200 µg/ml | $357.00 | |||
GnRH II Antibody (D-9) Alexa Fluor® 546 | sc-25344 AF546 | 200 µg/ml | $357.00 | |||
GnRH II Antibody (D-9) Alexa Fluor® 594 | sc-25344 AF594 | 200 µg/ml | $357.00 | |||
GnRH II Antibody (D-9) Alexa Fluor® 647 | sc-25344 AF647 | 200 µg/ml | $357.00 | |||
GnRH II Antibody (D-9) Alexa Fluor® 680 | sc-25344 AF680 | 200 µg/ml | $357.00 | |||
GnRH II Antibody (D-9) Alexa Fluor® 790 | sc-25344 AF790 | 200 µg/ml | $357.00 |