GnRH I Antibody (C-9): sc-373690
- GnRH I Antibody (C-9) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 43-77 within an internal region of GnRH I of human origin
- recommended for detection of GnRH I of human origin by WB, IP, IF and ELISA
- See GnRH I (A-4): sc-271918 for GnRH I antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GnRH I Antibody (C-9) for WB applications. These reagents are now offered in bundles with GnRH I Antibody (C-9) (see ordering information below).
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GnRH I Antibody (C-9) is a mouse monoclonal IgG2a antibody that detects gonadotropin-releasing hormone (GnRH) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GnRH plays a crucial role in the regulation of human reproduction by orchestrating the hypothalamic-pituitary-gonadal axis, which is essential for the release of luteinizing hormone and follicle-stimulating hormone from the anterior pituitary. This decapeptide is produced by hypothalamic neurons and is secreted in a pulsatile manner, ensuring the proper timing of hormonal release necessary for reproductive function. GnRH is expressed in the hypothalamus, acrosomal region of human sperm, anterior pituitary, and certain cancer cells, indicating diverse roles beyond reproduction. A second form, GnRH II, primarily found in the midbrain and expressed in tissues such as the kidney, bone marrow, and prostate, suggests additional functions that are yet to be fully understood. GnRH binding to specific G protein-coupled receptors in the pituitary is a critical step in regulating the synthesis and secretion of gonadotropins, highlighting GnRH′s importance in both normal physiology and potential pathological conditions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GnRH I Antibody (C-9) | sc-373690 | 200 µg/ml | $316.00 | |||
GnRH I Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-537863 | 200 µg Ab; 10 µg BP | $354.00 | |||
GnRH I Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-535297 | 200 µg Ab; 40 µg BP | $354.00 | |||
GnRH I Antibody (C-9): m-IgG2a BP-HRP Bundle | sc-548131 | 200 µg Ab; 10 µg BP | $354.00 | |||
GnRH I (C-9) Neutralizing Peptide | sc-373690 P | 100 µg/0.5 ml | $68.00 |