GnRH I Antibody (A-4): sc-271918

GnRH I Antibody (A-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects GnRH I protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-GnRH I antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GnRH I plays a crucial role in human reproduction through function in the hypothalamic-pituitary-gonadal axis, which is established early in fetal development. As a decapeptide, GnRH I is synthesized by hypothalamic neurons and released in a pulsatile manner into the capillary plexus of the median eminence, where GnRH I stimulates the secretion of luteinizing hormone and follicle-stimulating hormone from gonadotropic cells in the anterior pituitary. This regulation is vital for reproductive health, as GnRH I influences the development and function of the gonads. GnRH I is expressed in the acrosomal region of human sperm and in anterior pituitary tissue, as well as in certain cancer cells, indicating broader biological significance. A second form, GnRH II, primarily expressed outside the brain, suggests these peptides may have distinct and complementary roles in various physiological processes. The genes encoding GnRH-I and -II are located on human chromosomes 8p21-p11.2 and 20p13, respectively, highlighting their evolutionary importance.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GnRH I Antibody (A-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GnRH I Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GnRH I Antibody (A-4) Specifications

Alternate Product Name: Gonadotropin Releasing Hormone

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-92

Epitope Target: Progonadoliberin I precursor

Epitope Species: human

Product Reactivity/Detection: Progonadoliberin I precursor and Gonadoliberin I and GnRH-associated peptide I active peptides

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GnRH I Antibody (A-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred GnRH I antibody is GnRH I Antibody (HU11B): sc-32292.