GNA1 Antibody (A-3): sc-374519
- GNA1 Antibody (A-3) is a mouse monoclonal IgG2b κ GNA1 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 11-43 near the N-terminus of GNA1 of human origin
- GNA1 Antibody (A-3) is recommended for detection of GNA1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-GNA1 Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GNA1 Antibody (A-3) for WB applications. These reagents are now offered in bundles with GNA1 Antibody (A-3) (see ordering information below).
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GNA1 Antibody (A-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects GNA1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GNA1 (A-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Glucosamine 6-phosphate N-acetyltransferase (GNA1), also known as phosphoglucosamine transacetylase or phosphoglucosamine acetylase, is a crucial enzyme in UDP-GlcNAc biosynthesis pathway, which is essential for glycoprotein and glycolipid synthesis. GNA1 is a peripheral membrane protein containing one N-acetyltransferase domain and primarily localizes in Golgi apparatus and endosome, mapping to cytoband 14q22.1. GNA1 plays a vital role in catalyzing Acetyl-CoA and Glucosamine-6-phosphate conversion into Glucosamine-6-phosphate, a key step in UDP-GlcNAc formation, which is critical for various cellular processes, including cell signaling, cell adhesion, and extracellular matrix structural integrity. GNA1′s ability to facilitate these biochemical pathways underscores its importance in cellular function and development, making anti-GNA1 antibody (A-3) an invaluable tool for researchers studying these processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GNA1 Antibody (A-3) References:
- Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association. | Boehmelt, G., et al. 2000. J Biol Chem. 275: 12821-32. PMID: 10777580
- Reduced virulence of Candida albicans mutants lacking the GNA1 gene encoding glucosamine-6-phosphate acetyltransferase. | Mio, T., et al. 2000. Microbiology (Reading). 146 (Pt 7): 1753-1758. PMID: 10878139
- Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. | Boehmelt, G., et al. 2000. EMBO J. 19: 5092-104. PMID: 11013212
- The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase. | Peneff, C., et al. 2001. J Biol Chem. 276: 16328-34. PMID: 11278591
- A novel short-root gene encodes a glucosamine-6-phosphate acetyltransferase required for maintaining normal root cell shape in rice. | Jiang, H., et al. 2005. Plant Physiol. 138: 232-42. PMID: 15849305
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GNA1 Antibody (A-3) | sc-374519 | 200 µg/ml | $322.00 | |||
GNA1 Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-522766 | 200 µg Ab, 40 µg BP | $361.00 | |||
GNA1 Antibody (A-3): m-IgG2b BP-HRP Bundle | sc-549070 | 200 µg Ab; 10 µg BP | $361.00 | |||
GNA1 Antibody (A-3) AC | sc-374519 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GNA1 Antibody (A-3) HRP | sc-374519 HRP | 200 µg/ml | $322.00 | |||
GNA1 Antibody (A-3) FITC | sc-374519 FITC | 200 µg/ml | $336.00 | |||
GNA1 Antibody (A-3) PE | sc-374519 PE | 200 µg/ml | $349.00 | |||
GNA1 Antibody (A-3) Alexa Fluor® 488 | sc-374519 AF488 | 200 µg/ml | $364.00 | |||
GNA1 Antibody (A-3) Alexa Fluor® 546 | sc-374519 AF546 | 200 µg/ml | $364.00 | |||
GNA1 Antibody (A-3) Alexa Fluor® 594 | sc-374519 AF594 | 200 µg/ml | $364.00 | |||
GNA1 Antibody (A-3) Alexa Fluor® 647 | sc-374519 AF647 | 200 µg/ml | $364.00 | |||
GNA1 Antibody (A-3) Alexa Fluor® 680 | sc-374519 AF680 | 200 µg/ml | $364.00 | |||
GNA1 Antibody (A-3) Alexa Fluor® 790 | sc-374519 AF790 | 200 µg/ml | $364.00 | |||
GNA1 (A-3) Neutralizing Peptide | sc-374519 P | 100 µg/0.5 ml | $69.00 |