GMPS Antibody (C-5): sc-376163
- GMPS Antibody (C-5) is a mouse monoclonal IgG2b κ GMPS antibody, cited in 4 publications, provided at 200 µg/ml
- raised against a peptide mapping at the C-terminus of GMPS of human origin
- GMPS Antibody (C-5) is recommended for detection of GMPS of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and porcine
- Anti-GMPS Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for GMPS Antibody (C-5) for WB applications. These reagents are now offered in bundles with GMPS Antibody (C-5) (see ordering information below).
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SEE ALSO...
GMPS Antibody (C-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects GMPS protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GMPS (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GMPS protein, or guanine monophosphate synthetase, is a vital 693 amino acid cytoplasmic protein that plays a crucial role in purine biosynthesis, specifically catalyzing the final step in the GMP synthesis pathway through the ATP-dependent amination of XMP to GMP. This enzymatic activity is essential for the production of purines, which are fundamental for energy metabolism, cell signaling, and the synthesis of nucleic acids. GMPS exists as a homodimer and features a GMP-binding domain along with a glutamine amidotransferase type-1 domain, which are critical for catalytic function. Notably, chromosomal translocations involving GMPS have been linked to acute myeloid leukemias, highlighting potential role in carcinogenesis and making GMPS a significant target for research in cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GMPS Antibody (C-5) References:
- t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene. | Pegram, LD., et al. 2000. Blood. 96: 4360-2. PMID: 11110714
- Human GMP synthetase. | Page, T., et al. 1984. Int J Biochem. 16: 117-20. PMID: 6698284
- The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine. | Nakamura, J., et al. 1995. J Biol Chem. 270: 23450-5. PMID: 7559506
- Biochemical characterization of human GMP synthetase. | Nakamura, J. and Lou, L. 1995. J Biol Chem. 270: 7347-53. PMID: 7706277
- Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. | Hirst, M., et al. 1994. J Biol Chem. 269: 23830-7. PMID: 8089153
- Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3. | Fedorova, L., et al. 1997. Eur J Hum Genet. 5: 110-6. PMID: 9195163
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GMPS Antibody (C-5) | sc-376163 | 200 µg/ml | $322.00 | |||
GMPS Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-526007 | 200 µg Ab; 10 µg BP | $361.00 | |||
GMPS Antibody (C-5): m-IgG2b BP-HRP Bundle | sc-549660 | 200 µg Ab; 10 µg BP | $361.00 | |||
GMPS Antibody (C-5) AC | sc-376163 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GMPS Antibody (C-5) HRP | sc-376163 HRP | 200 µg/ml | $322.00 | |||
GMPS Antibody (C-5) FITC | sc-376163 FITC | 200 µg/ml | $336.00 | |||
GMPS Antibody (C-5) PE | sc-376163 PE | 200 µg/ml | $349.00 | |||
GMPS Antibody (C-5) Alexa Fluor® 488 | sc-376163 AF488 | 200 µg/ml | $364.00 | |||
GMPS Antibody (C-5) Alexa Fluor® 546 | sc-376163 AF546 | 200 µg/ml | $364.00 | |||
GMPS Antibody (C-5) Alexa Fluor® 594 | sc-376163 AF594 | 200 µg/ml | $364.00 | |||
GMPS Antibody (C-5) Alexa Fluor® 647 | sc-376163 AF647 | 200 µg/ml | $364.00 | |||
GMPS Antibody (C-5) Alexa Fluor® 680 | sc-376163 AF680 | 200 µg/ml | $364.00 | |||
GMPS Antibody (C-5) Alexa Fluor® 790 | sc-376163 AF790 | 200 µg/ml | $364.00 |