GMPS Activators
GMPS activators, as outlined in the table, include a range of chemical compounds that are hypothesized to indirectly influence the activity of Guanosine monophosphate synthase (GMPS). These activators primarily exert their influence through modulation of metabolic pathways and processes related to purine biosynthesis, the key area of GMPS involvement. They do not directly target GMPS but affect the cellular environment and the availability of precursors or intermediates necessary for GMPS function.
Compounds like AICAR and Methotrexate demonstrate the interconnected nature of the purine biosynthesis pathway and its regulation. AICAR, as an intermediate in this pathway, and Methotrexate, through its inhibitory effect on dihydrofolate reductase, exemplify the indirect mechanisms by which GMPS activity can be modulated. Similarly, Azathioprine and Ribavirin, by impacting the synthesis of guanine nucleotides, highlight the delicate balance of nucleotide pools that can influence GMPS. Mycophenolic acid and Allopurinol, targeting enzymes upstream of GMPS, further emphasize the role of purine metabolism regulation in GMPS activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Impacts ribonucleotide reductase, which can influence nucleotide availability and indirectly affect GMPS activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Affects thymidylate synthase, leading to imbalances in nucleotide pools that could indirectly influence GMPS activity. | ||||||
Folinic Acid | 58-05-9 | sc-337846A sc-337846B sc-337846 | 5 mg 25 mg 100 mg | $112.00 $297.00 $604.00 | ||
Used in combination with other drugs to modulate purine and pyrimidine synthesis, potentially influencing GMPS. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
A purine analog that can be incorporated into DNA and RNA, potentially impacting purine synthesis and GMPS activity. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Affects nucleotide synthesis and can have an indirect effect on GMPS through its impact on purine metabolism. | ||||||
Clofarabine | 123318-82-1 | sc-278864 sc-278864A | 10 mg 50 mg | $185.00 $781.00 | ||
A nucleoside analog that can disrupt nucleotide synthesis, potentially influencing GMPS activity. | ||||||