GM-CSFRα Antibody (8G6 BOT): sc-80649

GM-CSFRα Antibody (8G6 BOT) is a mouse monoclonal IgG antibody that detects GM-CSFRα in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). GM-CSFRα, or Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha, plays a crucial role in hematopoiesis and immune response by serving as a high-affinity receptor for GM-CSF, which is essential for the proliferation and differentiation of myeloid progenitor cells. GM-CSFRα is primarily located on the surface of hematopoietic cells, including granulocytes and monocytes, where GM-CSFRα facilitates the binding of GM-CSF, leading to the activation of downstream signaling pathways that promote cell survival, proliferation, and functional activation. Understanding the localization and function of GM-CSFRα is vital, as dysregulation of GM-CSFRα can contribute to various hematological disorders and impact immune responses, making GM-CSFRα a significant target for therapeutic interventions. Anti-GM-CSFRα antibody (8G6 BOT) serves as an invaluable tool for researchers studying these pathways and their implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GM-CSFRα Antibody (8G6 BOT) References:

1. Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation.  |  Atkins, GJ., et al. 2000. Bone. 26: 653-61. PMID: 10831938
2. HIV-1-transgene expression in rats decreases alveolar macrophage zinc levels and phagocytosis.  |  Joshi, PC., et al. 2008. Am J Respir Cell Mol Biol. 39: 218-26. PMID: 18314538
3. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival.  |  Melcher, M., et al. 2008. J Immunol. 180: 8048-56. PMID: 18523268
4. Toll-like receptor-mediated eosinophil-basophil differentiation: autocrine signalling by granulocyte-macrophage colony-stimulating factor in cord blood haematopoietic progenitors.  |  Reece, P., et al. 2013. Immunology. 139: 256-64. PMID: 23347362
5. Prognostic Relevance of Cytokine Receptor Expression in Acute Myeloid Leukemia: Interleukin-2 Receptor α-Chain (CD25) Expression Predicts a Poor Prognosis.  |  Nakase, K., et al. 2015. PLoS One. 10: e0128998. PMID: 26375984
6. Pulmonary pharmacodynamics of an anti-GM-CSFRα antibody enables therapeutic dosing that limits exposure in the lung.  |  Campbell, J., et al. 2016. MAbs. 8: 1398-1406. PMID: 27560702
7. Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation.  |  Cook, AD., et al. 2016. Arthritis Res Ther. 18: 287. PMID: 27908288
8. The VICM biomarker is released from activated macrophages and inhibited by anti-GM-CSFRα-mAb treatment in rheumatoid arthritis patients.  |  Mortensen, JH., et al. 2019. Clin Exp Rheumatol. 37: 73-80. PMID: 30418117
9. Expression of eosinophil β chain-signaling cytokines receptors, outer-membrane integrins, and type 2 inflammation biomarkers in severe non-allergic eosinophilic asthma.  |  Kalinauskaite-Zukauske, V., et al. 2019. BMC Pulm Med. 19: 158. PMID: 31438916
10. Construction and binding kinetics of a soluble granulocyte-macrophage colony-stimulating factor receptor alpha-chain-Fc fusion protein.  |  Monfardini, C., et al. 1998. J Biol Chem. 273: 7657-67. PMID: 9516471

The preferred GM-CSFRα antibody is GM-CSFRα Antibody (S-50): sc-456.