GlyRS Antibody (A-6): sc-373904
- GlyRS Antibody (A-6) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 136-165 within an internal region of GlyRS of human origin
- recommended for detection of GlyRS of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- TransCruz reagent for ChIP application (sc-373904 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GlyRS Antibody (A-6) for WB applications. These reagents are now offered in bundles with GlyRS Antibody (A-6) (see ordering information below).
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SEE ALSO...
GlyRS Antibody (A-6) is a mouse monoclonal IgG2b antibody that detects GlyRS in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GlyRS, or Glycyl-tRNA synthetase, is a crucial enzyme composed of 739 amino acids that plays a vital role in protein synthesis by catalyzing the attachment of glycine to its corresponding tRNA, thereby ensuring accurate translation of genetic information into functional proteins. GlyRS is predominantly expressed in tissues such as the brain and spinal cord, highlighting GlyRS importance in neural function and development. Notably, mutations in GlyRS are linked to Charcot-Marie-Tooth disease type 2D (CMT2D), an autosomal dominant disorder that leads to significant muscle weakness and atrophy, particularly affecting the upper extremities. Additionally, defects in GlyRS are implicated in distal hereditary muscular neuropathy type V (HMN5), which shares similarities with CMT2D but presents with less severe sensory involvement. Anti-GlyRS antibody (A-6) is an essential tool for researchers investigating molecular mechanisms underlying these neuropathies and broader implications of glycine metabolism in cellular function.
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GlyRS Antibody (A-6) References:
- Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V. | Antonellis, A., et al. 2003. Am J Hum Genet. 72: 1293-9. PMID: 12690580
- Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons. | Antonellis, A., et al. 2006. J Neurosci. 26: 10397-406. PMID: 17035524
- Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase. | Xie, W., et al. 2007. Proc Natl Acad Sci U S A. 104: 9976-81. PMID: 17545306
- Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. | Park, MC., et al. 2012. Proc Natl Acad Sci U S A. 109: E640-7. PMID: 22345558
- Functional substitution of a eukaryotic glycyl-tRNA synthetase with an evolutionarily unrelated bacterial cognate enzyme. | Chien, CI., et al. 2014. PLoS One. 9: e94659. PMID: 24743154
- Neuropathic pain model of peripheral neuropathies mediated by mutations of glycyl-tRNA synthetase. | Lee, SJ., et al. 2014. J Korean Med Sci. 29: 1138-44. PMID: 25120326
- Elaborate uORF/IRES features control expression and localization of human glycyl-tRNA synthetase. | Alexandrova, J., et al. 2015. RNA Biol. 12: 1301-13. PMID: 26327585
- Compound heterozygous mutations in glycyl-tRNA synthetase (GARS) cause mitochondrial respiratory chain dysfunction. | Nafisinia, M., et al. 2017. PLoS One. 12: e0178125. PMID: 28594869
- Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis. | Sleigh, JN., et al. 2017. Sci Rep. 7: 9216. PMID: 28835631
- A novel endogenous damage signal, glycyl tRNA synthetase, activates multiple beneficial functions of mesenchymal stem cells. | Park, SR., et al. 2018. Cell Death Differ. 25: 2023-2036. PMID: 29666468
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GlyRS Antibody (A-6) | sc-373904 | 200 µg/ml | $322.00 | |||
GlyRS Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-535336 | 200 µg Ab; 40 µg BP | $361.00 | |||
GlyRS Antibody (A-6): m-IgG2b BP-HRP Bundle | sc-549395 | 200 µg Ab; 10 µg BP | $361.00 | |||
GlyRS (A-6) Neutralizing Peptide | sc-373904 P | 100 µg/0.5 ml | $69.00 | |||
GlyRS Antibody (A-6) X | sc-373904 X | 200 µg/0.1 ml | $322.00 |