GlyRS Inhibitors
Glycyl-tRNA synthetase (GlyRS) inhibitors belong to a distinct chemical class that plays a crucial role in disrupting a fundamental cellular process known as protein synthesis. GlyRS is an essential enzyme responsible for attaching the amino acid glycine to its cognate transfer RNA (tRNA), a critical step in the translation of genetic information into functional proteins. Inhibitors targeting GlyRS specifically impede this aminoacylation process, leading to the disruption of protein synthesis and potentially influencing various cellular functions.
The chemical structures of GlyRS inhibitors are designed to interact selectively with the active site of GlyRS, hindering its ability to catalyze the formation of glycyl-tRNA. This interference in the aminoacylation process can have profound consequences on cellular homeostasis and function.Structural studies and computational analyses play a crucial role in guiding the optimization of these inhibitors, ensuring a rational approach to drug design. The exploration of GlyRS inhibitors not only contributes to our understanding of basic cellular processes but also holds potential implications for the development of novel strategies in various fields, including biochemical research and biotechnology. As researchers delve deeper into the intricacies of GlyRS inhibition, the insights gained may pave the way for innovative applications in diverse scientific domains
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1740.00 | ||
Halofuginone inhibits the aminoacylation of tRNA-Gly by GlyRS, thus preventing the production of glycine-charged tRNAs. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, which is required for the synthesis of purine nucleotides and the amino acids glycine and methionine. This can indirectly affect GlyRS. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), affecting purine biosynthesis. As purines are necessary for tRNA synthesis and function, this could indirectly affect GlyRS. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil inhibits thymidylate synthase, disrupting the synthesis of the pyrimidine thymidine, an essential component of DNA. Since DNA is required for the production of all proteins, including GlyRS, this could indirectly affect GlyRS. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Azathioprine gets converted into 6-mercaptopurine in the body, which inhibits purine synthesis. As purines are necessary for tRNA synthesis and function, this could indirectly affect GlyRS. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, which catalyzes the formation of deoxyribonucleotides from ribonucleotides. This can indirectly affect GlyRS by influencing DNA replication and repair. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
3′-Azido-3′-deoxythymidine is a reverse transcriptase inhibitor that can potentially affect the transcription and translation of GlyRS. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
Acivicin inhibits glutamine synthetase, which is involved in the conversion of glutamate and ammonia into glutamine. As glutamine is necessary for protein synthesis, this could indirectly affect GlyRS. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
2-Chloro-2′-deoxyadenosine is a purine analog and adenosine deaminase inhibitor. It could indirectly affect GlyRS by interrupting the synthesis and function of RNA and DNA. | ||||||