glypican-5 Antibody (F-3): sc-390838
- glypican-5 Antibody (F-3) is a mouse monoclonal IgG1 κ glypican-5 antibody provided at 200 µg/ml
- raised against amino acids 301-460 mapping within an internal region of glypican-5 of human origin
- glypican-5 Antibody (F-3) is recommended for detection of glypican-5 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-glypican-5 Antibody (F-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for glypican-5 Antibody (F-3) for WB applications. These reagents are now offered in bundles with glypican-5 Antibody (F-3) (see ordering information below).
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glypican-5 Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects glypican-5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-glypican-5 antibody (F-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Glypican-5, also known as GPC5, is a 572 amino acid protein primarily expressed in adult brain tissue, particularly localized to neurons, but is also detected in fetal brain, lung, and liver. GPC5 plays a crucial role in cellular signaling by modulating morphogen and growth factor activity, which are essential for regulating cellular division, growth, and differentiation. GPC5′s importance extends to neuronal growth and repair, highlighting potential impact on neurodevelopmental processes and neurodegenerative diseases. GPC5 is a member of the glypican-related integral membrane proteoglycan family, characterized by attachment to the cytoplasmic membrane via glycosyl phosphatidylinositol. GPC5 upregulation has been observed in active multiple sclerosis plaques, suggesting potential role in pathogenesis, as well as showing strong correlation with various lymphomas and other tumors, making GPC5 a significant target for research in cancer biology and neuroimmunology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
glypican-5 Antibody (F-3) References:
- GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13. | Paine-Saunders, S., et al. 1999. Genomics. 57: 455-8. PMID: 10329016
- Developmental roles of the glypicans. | De Cat, B. and David, G. 2001. Semin Cell Dev Biol. 12: 117-25. PMID: 11292377
- A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32. | Veugelers, M., et al. 2001. Matrix Biol. 20: 375-85. PMID: 11566272
- GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. | Yu, W., et al. 2003. J Hum Genet. 48: 331-335. PMID: 12721791
- Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. | Baranzini, SE., et al. 2009. Hum Mol Genet. 18: 767-78. PMID: 19010793
- Twelve new patients with 13q deletion syndrome: genotype-phenotype analyses in progress. | Quélin, C., et al. 2009. Eur J Med Genet. 52: 41-6. PMID: 19022413
- Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family. | Veugelers, M., et al. 1997. Genomics. 40: 24-30. PMID: 9070915
- Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. | Saunders, S., et al. 1997. Dev Biol. 190: 78-93. PMID: 9331333
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
glypican-5 Antibody (F-3) | sc-390838 | 200 µg/ml | $322.00 | |||
glypican-5 Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-530279 | 200 µg Ab; 10 µg BP | $361.00 | |||
glypican-5 Antibody (F-3): m-IgGκ BP-HRP Bundle | sc-523701 | 200 µg Ab, 40 µg BP | $361.00 | |||
glypican-5 Antibody (F-3): m-IgG1 BP-HRP Bundle | sc-543970 | 200 µg Ab; 20 µg BP | $361.00 | |||
glypican-5 Antibody (F-3) AC | sc-390838 AC | 500 µg/ml, 25% agarose | $424.00 | |||
glypican-5 Antibody (F-3) HRP | sc-390838 HRP | 200 µg/ml | $322.00 | |||
glypican-5 Antibody (F-3) FITC | sc-390838 FITC | 200 µg/ml | $336.00 | |||
glypican-5 Antibody (F-3) PE | sc-390838 PE | 200 µg/ml | $349.00 | |||
glypican-5 Antibody (F-3) Alexa Fluor® 488 | sc-390838 AF488 | 200 µg/ml | $364.00 | |||
glypican-5 Antibody (F-3) Alexa Fluor® 546 | sc-390838 AF546 | 200 µg/ml | $364.00 | |||
glypican-5 Antibody (F-3) Alexa Fluor® 594 | sc-390838 AF594 | 200 µg/ml | $364.00 | |||
glypican-5 Antibody (F-3) Alexa Fluor® 647 | sc-390838 AF647 | 200 µg/ml | $364.00 | |||
glypican-5 Antibody (F-3) Alexa Fluor® 680 | sc-390838 AF680 | 200 µg/ml | $364.00 | |||
glypican-5 Antibody (F-3) Alexa Fluor® 790 | sc-390838 AF790 | 200 µg/ml | $364.00 |