Glyoxalase II Antibody (F-12): sc-365025
- Glyoxalase II Antibody (F-12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 222-250 near the C-terminus of Glyoxalase II of human origin
- recommended for detection of Glyoxalase II of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Glyoxalase II Antibody (F-12) for WB applications. These reagents are now offered in bundles with Glyoxalase II Antibody (F-12) (see ordering information below).
QUICK LINKS
Glyoxalase II Antibody (F-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects Glyoxalase II of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Glyoxalase II antibody (F-12) plays a crucial role in studying the glyoxalase pathway, which is essential for the detoxification of harmful glucose degradation products. Glyoxalase II, also known as hydroxyacyl glutathione hydrolase or HAGH, functions as a thiolesterase, catalyzing the hydrolysis of S-D-lactoyl-glutathione to produce reduced glutathione and D-lactic acid. This enzyme is vital for maintaining cellular redox balance and protecting cells from oxidative stress. Glyoxalase II is a monomeric protein consisting of 260 amino acids and binds two zinc ions per subunit, which is critical for enzymatic activity. Glyoxalase II is predominantly located in the mitochondria and cytosol of mammalian cells, and elevated activity has been observed in breast cancer tissues compared to matched unaffected tissues, indicating potential as a therapeutic target. Glyoxalase II monoclonal antibody (F-12) is an invaluable tool for researchers investigating the role of glyoxalases in cancer and other diseases, providing insights into the mechanisms of cellular detoxification and the development of glyoxalase inhibitor drugs for cancer treatment.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glyoxalase II Antibody (F-12) | sc-365025 | 200 µg/ml | $322.00 | |||
Glyoxalase II Antibody (F-12): m-IgG Fc BP-HRP Bundle | sc-537761 | 200 µg Ab; 10 µg BP | $361.00 | |||
Glyoxalase II Antibody (F-12): m-IgGκ BP-HRP Bundle | sc-535131 | 200 µg Ab; 40 µg BP | $361.00 | |||
Glyoxalase II Antibody (F-12): m-IgG2a BP-HRP Bundle | sc-548111 | 200 µg Ab; 10 µg BP | $361.00 | |||
Glyoxalase II (F-12) Neutralizing Peptide | sc-365025 P | 100 µg/0.5 ml | $69.00 |