Glyoxalase II Antibody (C-6): sc-271663
- Glyoxalase II Antibody (C-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 222-250 near the C-terminus of Glyoxalase II of human origin
- recommended for detection of Glyoxalase II of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Glyoxalase II Antibody (C-6) for WB applications. These reagents are now offered in bundles with Glyoxalase II Antibody (C-6) (see ordering information below).
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Glyoxalase II Antibody (C-6) is a mouse monoclonal IgG1 antibody that detects Glyoxalase II in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Glyoxalase II plays a crucial role in the detoxification of glucose degradation products, specifically by catalyzing the hydrolysis of S-D-lactoyl-glutathione to produce reduced glutathione and D-lactic acid, which are vital for cellular health and metabolism. This enzyme, consisting of 260 amino acids, is localized in both the mitochondria and cytosol of mammalian cells, highlighting its importance in various cellular processes. Notably, Glyoxalase II exists solely as a monomer and binds two zinc ions per subunit, which is essential for enzymatic activity and structural stability. Research has shown that both Glyoxalase I and Glyoxalase II exhibit significantly higher activity levels in breast cancer tissues compared to matched unaffected tissues, suggesting that targeting the glyoxalase pathway with inhibitor drugs could be a promising strategy for cancer treatment. Anti-Glyoxalase II antibody (C-6) is an invaluable tool for researchers investigating the role of this enzyme in cancer biology and metabolic disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glyoxalase II Antibody (C-6) | sc-271663 | 200 µg/ml | $322.00 | |||
Glyoxalase II Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-537676 | 200 µg Ab; 10 µg BP | $361.00 | |||
Glyoxalase II Antibody (C-6): m-IgGκ BP-HRP Bundle | sc-535017 | 200 µg Ab; 40 µg BP | $361.00 | |||
Glyoxalase II Antibody (C-6): m-IgG1 BP-HRP Bundle | sc-545300 | 200 µg Ab; 20 µg BP | $361.00 | |||
Glyoxalase II (C-6) Neutralizing Peptide | sc-271663 P | 100 µg/0.5 ml | $69.00 |