Glycophorin C/D Antibody (A-5): sc-365542
- Glycophorin C/D Antibody (A-5) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- raised against amino acids 1-85 of Glycophorin C of human origin
- recommended for detection of Glycophorin C and D of human origin by WB, IP, IF and ELISA
- See Glycophorin A (R10): sc-53905 for Glycophorin C/D antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Glycophorin C/D Antibody (A-5) for WB applications. This reagent is now offered in a bundle with Glycophorin C/D Antibody (A-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Glycophorin C/D Antibody (A-5) is a mouse monoclonal IgG3 antibody that detects Glycophorin C in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Glycophorin C is a crucial sialoglycoprotein located on the surface of human erythrocytes, where Glycophorin C plays a significant role in maintaining the structural integrity of the red blood cell membrane and facilitating cell-cell interactions. Glycophorin C (A-5) antibody helps researchers study essential functions in erythrocytes, including prevention of hemolysis and overall cell stability in the bloodstream. The Glycophorin C gene, which maps to chromosome 2q14.3, can produce two isoforms through alternative splicing, with Isoform 1 encoding the full-length 128 amino acid protein and Isoform 2, also known as Glycophorin D, encoding a shorter 109 amino acid variant associated with the Yus subtype of the Gerbich phenotype. The presence of these isoforms and specific interactions with other membrane proteins are vital for understanding blood group phenotypes and their implications in transfusion medicine and immunology. Anti-Glycophorin C/D antibody (A-5) serves as an invaluable tool for researchers studying erythrocyte biology and blood group antigen expression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Glycophorin C/D Antibody (A-5) References:
- Functional aspects of red cell antigens. | Daniels, G. 1999. Blood Rev. 13: 14-35. PMID: 10225606
- Characterization of a Plasmodium falciparum erythrocyte-binding protein paralogous to EBA-175. | Mayer, DC., et al. 2001. Proc Natl Acad Sci U S A. 98: 5222-7. PMID: 11309486
- Glycophorin C content of human erythrocyte membrane is regulated by protein 4.1. | Reid, ME., et al. 1990. Blood. 75: 2229-34. PMID: 2346783
- Isolation of cDNA clones and complete amino acid sequence of human erythrocyte glycophorin C. | Colin, Y., et al. 1986. J Biol Chem. 261: 229-33. PMID: 2416746
- [Human erythrocyte glycophorin C as the receptor for EBA-140 Plasmodium falciparum merozoite ligand]. | Rydzak, J., et al. 2013. Postepy Hig Med Dosw (Online). 67: 1331-9. PMID: 24379273
- Human erythrocyte glycophorin C. Gene structure and rearrangement in genetic variants. | Colin, Y., et al. 1989. J Biol Chem. 264: 3773-80. PMID: 2917976
- Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging. | Klei, TRL., et al. 2018. Blood Adv. 2: 14-24. PMID: 29344581
- Structure of human erythrocyte glycophorin C deduced from cDNA analysis. | Cartron, JP., et al. 1986. Rev Fr Transfus Immunohematol. 29: 267-85. PMID: 3544149
- Identification of the membrane attachment sites for protein 4.1 in the human erythrocyte. | Hemming, NJ., et al. 1995. J Biol Chem. 270: 5360-6. PMID: 7890649
- Molecular genetics of hereditary elliptocytosis and hereditary spherocytosis. | Delaunay, J., et al. 1996. Ann Genet. 39: 209-21. PMID: 9037349
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Glycophorin C/D Antibody (A-5) | sc-365542 | 200 µg/ml | $322.00 | |||
Glycophorin C/D Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-522269 | 200 µg Ab, 40 µg BP | $361.00 |