Glycophorin C Antibody (BRIC100): sc-73567

Glycophorin C Antibody (BRIC100) is a mouse monoclonal IgG1 antibody that detects Glycophorin C in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Glycophorin C is a crucial sialoglycoprotein located on the surface of human erythrocytes, where Glycophorin C plays a significant role in maintaining the structural integrity of red blood cells and facilitating cell-cell interactions. Glycophorin C is essential for the proper functioning of erythrocytes, as Glycophorin C helps to prevent hemolysis and contributes to the overall stability of the cell membrane. The Glycophorin C gene, which maps to chromosome 2q14.3, can produce two isoforms through alternative splicing, with Isoform 1 encoding a full-length 128 amino acid protein and Isoform 2, also known as Glycophorin D, encoding a shorter 109 amino acid protein that is associated with the Yus subtype of the Gerbich phenotype. The presence of these isoforms and their specific interactions with other membrane proteins are vital for defining blood group phenotypes and can influence transfusion compatibility and susceptibility to certain diseases. Anti-Glycophorin C antibody (BRIC100) is an invaluable tool for researchers studying erythrocyte biology, blood group antigens, and related pathologies.

The preferred Glycophorin C antibody is Glycophorin C Antibody (E5): sc-59185.