Glycophorin C Inhibitors
Glycophorin C inhibitors target and inhibit the function of Glycophorin C, a sialoglycoprotein predominantly expressed in red blood cells (RBCs). Glycophorin C plays a vital role in maintaining the structural integrity and stability of the RBC membrane and is involved in cell-cell interactions, particularly in the context of erythrocyte aggregation and adhesion. It is characterized by a high content of sialic acid, contributing to the negative charge on the RBC surface.
The inhibitors of Glycophorin C are aimed at modulating these interactions and functions by binding to specific sites on the protein. The molecular structure of Glycophorin C inhibitors typically includes functional groups that are strategically designed to interact with the protein's extracellular domain. This design often involves a combination of hydrophilic and hydrophobic elements, along with various ring structures and charged groups, to optimize the binding affinity and specificity for Glycophorin C. The interaction between these inhibitors and Glycophorin C can influence the protein's function in cell adhesion and the overall properties of the RBC membrane.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Inhibits bacterial RNA polymerase, and in eukaryotic cells, might non-specifically inhibit nuclear RNA polymerase, potentially impacting GPC expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interacts with DNA and inhibits RNA polymerase, which could lead to a decrease in mRNA synthesis for various genes, including GPC. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Specifically inhibits RNA polymerase II, potentially decreasing mRNA synthesis for many genes, including GPC. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Known to inhibit transcription by RNA polymerase II, which could result in decreased expression of GPC. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Crosslinks DNA, which can inhibit DNA synthesis and transcription, potentially affecting GPC expression levels. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits RNA polymerase II-dependent transcription, possibly reducing GPC mRNA levels. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Terminates RNA chain elongation due to its resemblance to adenosine, potentially decreasing mRNA levels, including that of GPC. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
A small molecule that binds to rRNA and inhibits RNA polymerase I, potentially affecting global transcription and GPC expression. | ||||||
(+)-Irinotecan | 97682-44-5 | sc-269253 | 10 mg | $62.00 | 1 | |
Inhibits DNA topoisomerase I, leading to reduced transcription and potentially affecting GPC mRNA levels. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
A nucleoside analog that inhibits DNA polymerase, potentially reducing transcription and hence GPC expression. | ||||||