Glycophorin C Antibody (BGRL100): sc-59184

Glycophorin C Antibody (BGRL100) is a mouse monoclonal IgG1 antibody that detects Glycophorin C in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Glycophorin C is a crucial sialoglycoprotein located in the membrane of human erythrocytes, where anti-Glycophorin C antibody (BGRL100) plays a significant role in maintaining the structural integrity and stability of red blood cells. Glycophorin C spans the membrane once, with its amino-terminal end exposed to the extracellular environment, which is essential for its function in cell-cell interactions and providing a negative charge that helps prevent red blood cell aggregation. The Glycophorin C gene, located on chromosome 2q14.3, can produce two isoforms through alternative splicing, with Isoform 1 encoding the full-length 128 amino acid protein and Isoform 2, also known as Glycophorin D, encoding a shorter 109 amino acid variant that is associated with the Yus subtype of the Gerbich phenotype. The presence of these isoforms and their specific interactions with other proteins are vital for understanding blood group phenotypes and their implications in transfusion medicine and immunology. Glycophorin C monoclonal antibody (BGRL100) is an invaluable tool for researchers studying erythrocyte biology and blood group antigen expression.

The preferred Glycophorin C antibody is Glycophorin C Antibody (E5): sc-59185.