Glucose Transporter Glut5 Antibody (E-2): sc-271055

Glut5 Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Glut5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Glut5 antibody (E-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Glut5, encoded by the GLUT5 gene located on the short arm of human chromosome 1, consists of 501 amino acids and functions primarily as a facilitative transporter for fructose in the small intestine. Glut5′s role is crucial, enabling fructose absorption as a key alternative energy source, especially in diets rich in this carbohydrate. Glut5 expression increases significantly in response to a fructose-enriched diet, highlighting an adaptive function in nutrient absorption. Glut5 shows predominant expression in the small intestine, with lower levels in kidney, skeletal muscle, and adipose tissue, indicating specialized roles in nutrient uptake. Glut5 localization to enterocyte plasma membranes underscores importance in facilitating fructose transport across cellular barriers, contributing to overall metabolic homeostasis.

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Glucose Transporter Glut5 Antibody (E-2) References:

1. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity.  |  Doege, H., et al. 2000. J Biol Chem. 275: 16275-80. PMID: 10821868
2. Biochemical and immunocytochemical localization of the 'GLUT5 glucose transporter' in human skeletal muscle.  |  Hundal, HS., et al. 1992. Biochem J. 286 (Pt 2): 339-43. PMID: 1530566
3. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).  |  Kayano, T., et al. 1990. J Biol Chem. 265: 13276-82. PMID: 1695905
4. GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase.  |  Liang, RJ., et al. 2021. Cancer Metab. 9: 12. PMID: 33762003
5. GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis.  |  Basu, S., et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321: G232-G242. PMID: 34133236
6. Glut5 Knockdown in the Nucleus Tractus Solitarii Alleviates Fructose-Induced Hypertension in Rats.  |  Wu, CJ., et al. 2022. J Nutr. 152: 448-457. PMID: 34687200
7. IL-6/STAT3 Axis Activates Glut5 to Regulate Fructose Metabolism and Tumorigenesis.  |  Huang, X., et al. 2022. Int J Biol Sci. 18: 3668-3675. PMID: 35813468
8. GLUT5-overexpression-related tumorigenic implications.  |  Hadzi-Petrushev, N., et al. 2024. Mol Med. 30: 114. PMID: 39107723
9. Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5.  |  Rand, EB., et al. 1993. Am J Physiol. 264: G1169-76. PMID: 8333543
10. Cloning and increased expression with fructose feeding of rat jejunal GLUT5.  |  Inukai, K., et al. 1993. Endocrinology. 133: 2009-14. PMID: 8404647
11. GLUT5 expression and fructose transport in human skeletal muscle.  |  Hundal, HS., et al. 1998. Adv Exp Med Biol. 441: 35-45. PMID: 9781312
12. Biochemical and functional characterization of the GLUT5 fructose transporter in rat skeletal muscle.  |  Darakhshan, F., et al. 1998. Biochem J. 336 (Pt 2): 361-6. PMID: 9820812

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Glucose Transporter Glut5 Antibody (E-2) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-Glucose Transporter Glut5 Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Glucose Transporter Glut5 Antibody (E-2) Specifications

Alternate Product Name: Glut5

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 221-420

Epitope Target: Glut5

Epitope Species: human

Product Reactivity/Detection: Glut5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for Glucose Transporter Glut5 Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin